지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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In this study, we examined the effect of luteolin to enhance TRAIL-induced anticancer effect in SK-Hep1 cells. We found that combined use of TRAIL with luteolin markedly enhanced the cytotoxicity compared to either agent alone by inducing apoptosis. Furthermore, combined treatment of TRAIL with luteolin significantly induced activation of death receptor pathway-related proteins as well as PARP-cleavage and activation of effector caspases. Also, our result indicated that upregulation of DR4 and DR5 by luteolin combination may contribute to enhanced susceptibility of SK-Hep1 cells to TRAIL.
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참고문헌 (29)
참고문헌 신청
Ashkenazi, A. / 1999 / Safety and antitumor activity of recombinant soluble Apo2 ligand / J. Clin. Invest 104:155
Roth, W. / 1999 / Locoregional Apo2L/TRAIL eradicates intracranial human malignant glioma xenografts in athymic mice in the absence of neurotoxicity / Biochem. Bioph. Res. Co 265:479
Walczak, H. / 1999 / Tumoricidal activity of tumor necrosis factorrelated apoptosis-inducing ligand in vivo / Nat. Med 5:157
Hinz, S. / 2000 / Bcl-XL protects pancreatic adenocarcinoma cells against CD95- and TRAIL-receptor-mediated apoptosis / Oncogene 19:5477
Zhang, Y. / 2008 / TRAIL resistance of breast cancer cells is associated with constitutive endocytosis of death receptors 4 and 5 / Mol. Cancer Res 6:1861
Roth, W. / 1999 / Locoregional Apo2L/TRAIL eradicates intracranial human malignant glioma xenografts in athymic mice in the absence of neurotoxicity / Biochem. Bioph. Res. Co 265:479
Walczak, H. / 1999 / Tumoricidal activity of tumor necrosis factorrelated apoptosis-inducing ligand in vivo / Nat. Med 5:157
Hinz, S. / 2000 / Bcl-XL protects pancreatic adenocarcinoma cells against CD95- and TRAIL-receptor-mediated apoptosis / Oncogene 19:5477
Zhang, Y. / 2008 / TRAIL resistance of breast cancer cells is associated with constitutive endocytosis of death receptors 4 and 5 / Mol. Cancer Res 6:1861
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