지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Most antineoplastic agents are nonselective in their mechanism of action, affecting noncancerous as well as cancerous cells, and resulting in acute effects such as irritation of mucous membranes and chronic effects such as genotoxicity, teratogenicity, and carcinogenicity. Healthcare workers occupationally exposed to antineoplastic agents are at risk. The present study aimed to develop and apply methods to monitor occupational exposure to antineoplastic agents, using cyclophosphamide (CP) as the model compound. To monitor environmental and biological exposure, potentially contaminated surfaces were wiped and 24 hour urine samples were collected from workers. Liquid chromatography combined with tandem mass spectrometry was performed, with a limit of detection of 0.05 ng/ml. Measurable amounts of CP were detected on 92% of the sampled surfaces, with a geometric mean of 175.22 $ng/m^2$. Despite the environmental contamination of the model compound, CP was below the detection limit in all urine samples. If workplace contamination cannot be completely avoided, it is importance to reduce exposure to the lowest possible levels. To this aim, efforts to minimize occupational exposure along with biological and environmental monitoring are required. The standardized sampling techniques, and specific and sensitive analytical methods reported in this study may be helpful in assessing occupational exposure and devising strategies to reduce exposure.
목차
등록된 정보가 없습니다.
참고문헌 (46)
참고문헌 신청
ASHP (American Society of Hospital Pharmacists) / 1990 / ASHP technical assistance bulletin on handling cytotoxic and hazardous drugs / Am. J. Hosp. Pharm 47:1033
NIOSH (National Institute for Occupational Safety and Health) / NIOSH alert: Preventing occupational exposure to antineoplastic and other hazardous drugs in health care settings
Sessink, P. J. M / 1999 / Drugs hazardous to healthcare workers: evaluation of methods for monitoring occupational exposure to cytostatic drugs / Drug. Saf 20:347
ASHP (American Society of Hospital Pharmacists) / 2006 / ASHP guidelines on handling hazardous drug / Am. J. Health-Syst. Pharm 63:1172
IARC (International Agency for Research on Cancer) / 1979 / IARC monographs: chemicals and industrial processes associated with cancer in humans / Lyons, France
NIOSH (National Institute for Occupational Safety and Health) / NIOSH alert: Preventing occupational exposure to antineoplastic and other hazardous drugs in health care settings
Sessink, P. J. M / 1999 / Drugs hazardous to healthcare workers: evaluation of methods for monitoring occupational exposure to cytostatic drugs / Drug. Saf 20:347
ASHP (American Society of Hospital Pharmacists) / 2006 / ASHP guidelines on handling hazardous drug / Am. J. Health-Syst. Pharm 63:1172
IARC (International Agency for Research on Cancer) / 1979 / IARC monographs: chemicals and industrial processes associated with cancer in humans / Lyons, France
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