지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
A Softgel is an oral dosage form for medicine similar to capsules and softgel dosage form offers several advantages over other oral dosage forms, such as delivering a liquid matrix designed to solubilize and improve the oral bioavailability of a poorly soluble compound as a unit dose solid dosage form, delivering low and ultra-low doses of a compound. This study aimed to qualify a proprietary vegetable soft capsule which contains modified starch and carrageenan as capsule shell components compare to the conventional gelatin softgel. Four kinds of samples were prepared with vegetable and gelatin capsule shell, respectively. Morphology of capsule shell, mechanical strength of capsule, and hygroscopic properties were studied for comparing the quality attributes of softgel. Short-term stability against heat and moisture was also investigated in this study. Vegetable capsule shell showed better mechanical strength, physical stability and disintegration time for temperature and humidity than those of conventional gelatin capsule shell with four different filling materials used frequently as soft capsule form. Conclusively, this vegetable capsule shell polymer system can replace easily gelatin-shell systems and additionally allows encapsulation of lipid fills at high temperatures that are semisolid or solid-like at room temperature.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Lipinski, C. A / 1997 / Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings / Adv. Drug Deliv. Rev 23:3
Lipinski, C. A / 2003 / Physicochemical properties in drug design / Novel Concepts and Technologies to Accelerate Drug Development
Agharkar, S / 1976 / Enhancement of solubility of drug salts by hydrophilic counter-ions: Properties of organic salts of an anti-malarial drug / J. Pharm. Sci 65:747
Bastin, R. J / 2000 / Salt selection and optimisation procedures for pharmaceutical new chemical entities / Org. Proc. Res. Dev 4:427
Serajuddin, A. T. M / 2007 / Salt formation to improve drug solubility / Adv. Drug Deliv. Rev 59:603
Lipinski, C. A / 2003 / Physicochemical properties in drug design / Novel Concepts and Technologies to Accelerate Drug Development
Agharkar, S / 1976 / Enhancement of solubility of drug salts by hydrophilic counter-ions: Properties of organic salts of an anti-malarial drug / J. Pharm. Sci 65:747
Bastin, R. J / 2000 / Salt selection and optimisation procedures for pharmaceutical new chemical entities / Org. Proc. Res. Dev 4:427
Serajuddin, A. T. M / 2007 / Salt formation to improve drug solubility / Adv. Drug Deliv. Rev 59:603
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