지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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The present study was undertaken to investigate the influence of sulforaphane on vascular smooth muscle contractility and to determine the mechanism involved. We hypothesized that sulforaphane, the primary ingredient of broccoli of cruciferous vegetables, plays a role in vascular relaxation through inhibition of Rho-kinase in rat aortae. Intact of denuded arterial rings from male Sprague-Dawley rats were used and isometric tensions were recorded using a computerized data acquisition system. Interestingly, sulforaphane significantly inhibited fluoride, phorbol ester or thromboxane $A_2$ mimetic-induced contraction in denuded muscles suggesting that additional pathways different from endothelial nitric oxide synthesis such as inhibition of Rho-kinase or MEK might be involved in the vasorelaxation. Furthermore, sulforaphane inhibited thromboxane $A_2$-induced increases in pERK1/2 levels suggesting the mechanism including inhibition of thromboxane $A_2$-induced increases in ERK1/2 phosphorylation. This study provides evidence that sulforaphane induces vascular relaxation through inhibition of Rho-kinase or MEK in rat aortae.
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참고문헌 (24)
참고문헌 신청
Lydakis, C. / 1997 / Diet, lifestyle and blood pressure / Coronary Health Care 1:130
Marn, C. / 2013 / Endothelial aging associated with oxidative stress can be modulated by a healthy mediterranean diet / Int. J. Mol. Sci 14:8869
Favero, G. / 2014 / Endothelium and its alterations in cardiovascular diseases:life style intervention / Biomed. Res. Int
Zhang, Y. / 1992 / A major inducer of anticarcinogenic protective enzymes from broccoli:isolation and elucidation of structure / Proc. Natl. Acad. Sci. USA 89:2399
Zhao, H. D. / 2010 / Sulforaphane protects liver injury induced by intestinal ischemia reperfusion through Nrf2-ARE pathway / World J. Gastroenterol 16:3002
Marn, C. / 2013 / Endothelial aging associated with oxidative stress can be modulated by a healthy mediterranean diet / Int. J. Mol. Sci 14:8869
Favero, G. / 2014 / Endothelium and its alterations in cardiovascular diseases:life style intervention / Biomed. Res. Int
Zhang, Y. / 1992 / A major inducer of anticarcinogenic protective enzymes from broccoli:isolation and elucidation of structure / Proc. Natl. Acad. Sci. USA 89:2399
Zhao, H. D. / 2010 / Sulforaphane protects liver injury induced by intestinal ischemia reperfusion through Nrf2-ARE pathway / World J. Gastroenterol 16:3002
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