지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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The present study was undertaken to investigate the influence of curcumin on vascular smooth muscle contractility and to determine the mechanism involved. We hypothesized that curcumin, the primary ingredient of Curcuma longa, plays a role in vascular relaxation through inhibition of Rho-kinase in rat aortae. Denuded arterial rings from male Sprague-Dawley rats were used and isometric tensions were recorded using a computerized data acquisition system. Interestingly, curcumin inhibited fluoride-induced contraction but didn't inhibit phorbol ester-induced contraction suggesting that additional pathways different from endothelial nitric oxide synthesis might be involved in the vasorelaxation. Furthermore, curcumin significantly inhibited fluoride-induced increases in pMYPT1 levels. On the other hand, it didn't significantly inhibit phorbol ester-induced increases in pERK1/2 levels suggesting the mechanism involving inhibition of fluoride-induced MYPT1 phosphorylation. This study provides evidence that curcumin induces vascular relaxation through inhibition of Rho-kinase in rat aortae.
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참고문헌 (16)
참고문헌 신청
Lydakis, C / 1997 / Diet, lifestyle and blood pressure / Coronary Health Care 1:130
Singh, M / 2011 / Curcumin counteracts the proliferative effect of estradiol and induces apoptosis in cervical cancer cells / Mol. Cell. Biochem 347:1
Li, R / 2011 / Qualitative and quantitative analysis of curcuminoids in herbal medicines derived from Curcuma species / Food Chemistry 126:1890
Somlyo, A. P / 1994 / Signal transduction and regulation in smooth muscle / Nature 372:231
Somlyo, A. P / 1998 / From pharmacomechanical coupling to G-proteins and myosin phosphatase / Acta. Physiol. Scand 164:437
Singh, M / 2011 / Curcumin counteracts the proliferative effect of estradiol and induces apoptosis in cervical cancer cells / Mol. Cell. Biochem 347:1
Li, R / 2011 / Qualitative and quantitative analysis of curcuminoids in herbal medicines derived from Curcuma species / Food Chemistry 126:1890
Somlyo, A. P / 1994 / Signal transduction and regulation in smooth muscle / Nature 372:231
Somlyo, A. P / 1998 / From pharmacomechanical coupling to G-proteins and myosin phosphatase / Acta. Physiol. Scand 164:437
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