지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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A series of new alkylselenoallylthiopyridazine 12~18 was synthesized as expected to retain anticancer activity. Synthetic route for the final compounds 12~18 was proceeded with diselenylation, hydrolysis/alkylation and allylthiolation from 3,6-dichloropyridazine 1. Dichloropyridazinyl diselenide 2 was prepared from the diselenide anion using synthetic route of Bhasin. Diselenide 2 can be reduced to 3-chloropyridazinyl selenolate anion using hydrazine hydrate at rt in the presence of NaOH in THF. The anion thus formed reacts readily with alkyl halide to give the 3-alkylseleno-6-chloropyridazine 3~11. 3-Alkylseleno-6-allylthiopyridazines 12~18 were prepared from 3~11 with allylmercaptan and sodium methoxide.
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참고문헌 (14)
참고문헌 신청
Rotruck, J. T / 1972 / Prevention of oxidative damage to rat erythrocytes by dietary selenium / J. Nutr 120:689
Arner, E. S / 2000 / Physiological functions of thioredoxin and thioredoxin reductase / Eur. J. Biochem 267:6102
Huawei, Z / 2008 / Selenium as an anticancer nutrient: roles in cell proliferation and tumor cell invasion / J Nutr 19:1
Karam, E. B / 2004 / Mechanisms of mammary cancer chemoprevention by organoselenium compounds / Mutation Research 551:181
Tarze, A / 2007 / Extracellular production of hydrogen selenide accounts for thiol-assisted toxicity of selenite against Saccharomyces cerevisiae / J. Biol. Chem 282:875
Arner, E. S / 2000 / Physiological functions of thioredoxin and thioredoxin reductase / Eur. J. Biochem 267:6102
Huawei, Z / 2008 / Selenium as an anticancer nutrient: roles in cell proliferation and tumor cell invasion / J Nutr 19:1
Karam, E. B / 2004 / Mechanisms of mammary cancer chemoprevention by organoselenium compounds / Mutation Research 551:181
Tarze, A / 2007 / Extracellular production of hydrogen selenide accounts for thiol-assisted toxicity of selenite against Saccharomyces cerevisiae / J. Biol. Chem 282:875
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