지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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The objective of this study is to evaluate the synergic effects of combined treatment with taurine and cisplatin in human breast cancer, MCF-7 cells. For this study, MCF-7 cells were treated with taurine (5, 10, and 20 mM) and cisplatin (0.5 ${\mu}M$) for 48 and 72 hrs. Co-treatment of cisplatin with taurine decreased cell proliferation more compared with cisplatin alone. Reduced cell proliferation was caused by apoptosis. Therefore we investigated the apoptotic cells. After treatment of cisplatin and taurine, apoptotic cells were slightly increased. Apoptosis-related proteins, cleaved caspases and cytochrome c were increased. The present study suggests that combination treatment of cisplatin with taurine enhance anticancer activity of cisplatin in MCF-7 cells.
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참고문헌 (33)
참고문헌 신청
Park, B / 2012 / Cancer screening status in Korea, 2011: results from the Korean National Cancer Screening Survey / Asian Pac. J. Cancer Prev 4:1187
Downs-Holmes, C / 2011 / Breast cancer: overview & updates / Nurse Pract 36:20
Cazzaniga, M / 2012 / Breast cancer chemoprevention: old and new approaches / J. Biomed. Biotechnol :985620
Lewis, C / 1994 / A review of the use of chemoprotectants in cancer chemotherapy / Drug Saf 11:153
Links, M / 1999 / Chemoprotectants: a review of their clinical pharmacology and therapeutic efficacy / Drugs 57:293
Downs-Holmes, C / 2011 / Breast cancer: overview & updates / Nurse Pract 36:20
Cazzaniga, M / 2012 / Breast cancer chemoprevention: old and new approaches / J. Biomed. Biotechnol :985620
Lewis, C / 1994 / A review of the use of chemoprotectants in cancer chemotherapy / Drug Saf 11:153
Links, M / 1999 / Chemoprotectants: a review of their clinical pharmacology and therapeutic efficacy / Drugs 57:293
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