지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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The aim of present study was to investigate the possible influence and related mechanism of alcohol on the arterial contraction. Vascular contraction involves the activation of thick or thin filament pathway. However, there are no reports addressing the question whether this pathway is involved in alcohol-induced regulation. We hypothesized that alcohol plays a role in vascular contraction evoked by a vasoconstrictor in rat aortae regardless of endothelial function. Denuded arterial rings from male rats were used and isometric contractions were recorded using a computerized data acquisition system. Interestingly, alcohol at a low concentration (3% v/v) inhibited thromboxane $A_2$ or phorbol ester-induced contraction with endothelial function but at a high concentration (10%) didn't inhibit and rather increased the contraction in the denuded muscle. Therefore, alcohol at a low concentration decreases the contraction and alcohol at a high concentration increases the contraction suggesting that additional pathways different from endothelial nitric oxide synthesis might be involved in the regulation of contractility. In conclusion, alcohol has some effect on the regulation of contractility regardless of endothelial function.
목차
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참고문헌 (17)
참고문헌 신청
Henriksson, K.M. / 2003 / Body composition, ethnicity and alcohol consumption as determinants for the development of blood pressure in a birth cohort of young middle-aged men / Eur. J. Epidemiol 18:955
Agarwal, D. P. / 2001 / Does moderate alcohol intake protect against coronary heart disease? / Indian Heart J 53:224
Agarwal, D. P. / 2002 / Cardioprotective effects of light-moderate consumption of alcohol: a review of putative mechnism / Alcohol. Alcohol 37:409
Corrao, G. / 2000 / Alcohol and coronary heart disease: a meta analysis / Addiction 95:1505
Toda, N. / 2010 / Vascular actions of nitric oxide as affected by exposure to alcohol / Alcohol. Alcohol 45:347
Agarwal, D. P. / 2001 / Does moderate alcohol intake protect against coronary heart disease? / Indian Heart J 53:224
Agarwal, D. P. / 2002 / Cardioprotective effects of light-moderate consumption of alcohol: a review of putative mechnism / Alcohol. Alcohol 37:409
Corrao, G. / 2000 / Alcohol and coronary heart disease: a meta analysis / Addiction 95:1505
Toda, N. / 2010 / Vascular actions of nitric oxide as affected by exposure to alcohol / Alcohol. Alcohol 45:347
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