지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Liver is the major organ to regulate the systemic glucose homeostasis and insulin resistance. Excess energy intake leads to triglyceride accumulation in adipose tissue first and subsequent accumulation in liver, resulting in obesity and type 2 diabetes. The representative pathological animal model for obesity associated insulin resistance is a high fat diet (HFD) fed mice model. Given the essential role of liver fat accumulation in developing systemic insulin resistance in obesity, I measured the liver triglyceride contents in HFD fed mice as a function of time. As such, in this report, I show the cause and effect relationship with regard to time during a HFD feeding between a variety of factors that are related to systemic insulin resistance including glucose intolerance, plasma insulin level and inflammatory gene expression in liver and adipose tissue.
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참고문헌 (3)
참고문헌 신청
Lee, Y. S. / 2011 / Inflammation is necessary for long-term but not short-term high-fat diet-induced insulin resistance / Diabetes 60:2474
Schenk, S. / 2008 / Insulin sensitivity modulation by nutrients and inflammation / J. Clin. Invest 118:2992
Olefsky, J. M. / 2010 / Macrophages, inflammation, and insulin resistance / Annu. Rev. Physiol 72:219
Schenk, S. / 2008 / Insulin sensitivity modulation by nutrients and inflammation / J. Clin. Invest 118:2992
Olefsky, J. M. / 2010 / Macrophages, inflammation, and insulin resistance / Annu. Rev. Physiol 72:219
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