지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Although statins, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, have been shown to increase melanin synthesis, the exact mechanism of this action is not fully understood. In this study we investigated the possible involvement of intracellular $Ca^{2+}$ signal in the mechanism of stimulation of melanin synthesis induced by lovastatin in B16 cells. Lovastatin stimulated the production of melanin in a dose-dependent manner in the cells. Treatment with mevalonate, FPP and GGPP, precursors of cholesterol, did not significantly suppress the lovastatin-induced melanin production, suggesting that inhibition of cholesterol synthesis may not be involved in the mechanism of the action of lovastatin. In addition, lovastatin did not significantly alter the cAMP concentration and the stimulated production of melanin by lovastatin was not significantly changed by treatment with H89, a potent inhibitor of protein kinase A, which demonstrates that cAMP pathway may not be involved. However, lovastatin increased intracellular $Ca^{2+}$ concentration in a dose-related fashion. Treatment with EGTA, an extracellular $Ca^{2+}$ chelator did not significantly alter the lovastatin-induced intracellular $Ca^{2+}$ increase and melanin synthesis, whereas intracellular $Ca^{2+}$ reduction with BAPTA/AM and intracellular $Ca^{2+}$ release blockers (dantrolene and TMB-8) completely blunted these actions of lovastatin. Taken together, these results suggest that the intracellular $Ca^{2+}$ release may play an important role in the lovastatin-induced stimulation of melanin synthesis in B16 cells. These results further suggest that lovastatin may be useful for the treatment of hypopigmentation disorders, such as vitiligo.
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참고문헌 (24)
참고문헌 신청
Boissy, R. E / 2003 / Melanosome transfer to and translocation in the keratinocyte. Exp / Dermatol 12(Suppl 2):5
Gillbro, J. M / 2011 / The melanogenesis and mechanisms of skin-lightening agents-existing and new approaches / Int. J. Cosmet. Sci 33:210
Schallreuter, K. U / 2008 / Regulation of melanogenesis-controversies and new concepts / Exp. Dermatol 17:395
Chang, T. S / 2009 / An updated review of tyrosinase inhibitors / Int. J. Mol. Sci 10:2440
Sposito, A. C / 2002 / Statin therapy in acute coronary syndromes: mechanistic insight into clinical benefit. Arterioscler / Thromb. Vasc. Biol 22:1524
Gillbro, J. M / 2011 / The melanogenesis and mechanisms of skin-lightening agents-existing and new approaches / Int. J. Cosmet. Sci 33:210
Schallreuter, K. U / 2008 / Regulation of melanogenesis-controversies and new concepts / Exp. Dermatol 17:395
Chang, T. S / 2009 / An updated review of tyrosinase inhibitors / Int. J. Mol. Sci 10:2440
Sposito, A. C / 2002 / Statin therapy in acute coronary syndromes: mechanistic insight into clinical benefit. Arterioscler / Thromb. Vasc. Biol 22:1524
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