지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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In our previous studies, 6-hydroxy-7-methoxychroman-2-carboxylic acid N-phenylamide (KL-1156) was identified as a good inhibitor of nuclear factor-${\kappa}B$ (NF-${\kappa}B$) activation. In continuation of our study, we describe the structure-activity relationship of chroman derivatives containing N-arylalkyl groups and their NF-${\kappa}B$ inhibitory activities. In addition, inhibitory effects of cell proliferation are evaluated against human cancer cell lines (NCI-H23 and PC-3). The most active compounds 3i and 3j contained diphenylethyl and diphenylpropyl side chain on amide nitrogen.
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참고문헌 (7)
참고문헌 신청
Beg, A. A / 1996 / An essential role for NF-κB in preventing TNF-α-induced cell death / Science 274:782
Alcamo, E / 2001 / Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-κB in leukocyte recruiment / J. Immunol 167:1592
Kumar, A / 2004 / Nuclear factor-κB: its role in health and disease / J. Mol. Med 82:434
Kim, B. H / 2004 / Inhibitory mechanism of chroman compound on LPS-induced nitric oxide production and nuclear factor-kappaB activation / Biochem. Biophys. Res. Commun 325:223
Jae-Hwan Kwak / 2008 / Synthesis of Chroman-2-carboxylic Acid N-(substituted)phenylamides and Their Inhibitory Effect on Nuclear Factor-κB (NF-κB) Activation / Archives of Pharmacal Research 31(2):133~141
Alcamo, E / 2001 / Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-κB in leukocyte recruiment / J. Immunol 167:1592
Kumar, A / 2004 / Nuclear factor-κB: its role in health and disease / J. Mol. Med 82:434
Kim, B. H / 2004 / Inhibitory mechanism of chroman compound on LPS-induced nitric oxide production and nuclear factor-kappaB activation / Biochem. Biophys. Res. Commun 325:223
Jae-Hwan Kwak / 2008 / Synthesis of Chroman-2-carboxylic Acid N-(substituted)phenylamides and Their Inhibitory Effect on Nuclear Factor-κB (NF-κB) Activation / Archives of Pharmacal Research 31(2):133~141
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