지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Sipjundaebo-tang was a well-known restorative traditional herbal prescription that used to treat anemia, anorexia, fatigue and inflammation. In this study, we examined the bioconversion of compounds in the Sipjundaebo-tang (SJ) and fermented Sipjundaebo-tang with Lactobacillus fermentum KFRI 164 (FSJ) using established HPLC-DAD method. The chromatogram of FSJ has shown that the contents of six bioactive compounds 5-HMF, paeoniflorin, ferulic acid, cinnam aldehyde, decursin, glycyrrhizin in SJ has decreased. And the contents of unknown compounds (1), (2), (3), (4) and (5) in FSJ were higher than each contents of SJ. The antioxidant activities of SJ and FSJ were conducted by DPPH free radical and Hydrogen peroxide ($H_2O_2$) scavenging assay. Electron donating activity (EDA, %) value of FSJ has shown higher than 21.9% and 14.5% at a concentration of 0.5 mg/ml for DPPH radical scavenging activity and $H_2O_2$ scavenging activity, respectively. Also, the neuroprotective activities of SJ and FSJ against glutamate-induced oxidative stress in a mouse hippocampal cell line (HT22) were evaluated by MTT assay. As a result, FSJ has shown higher neuroprotective activity than 56.5% comparing with SJ. In conclusion, the fermented SJ using microorganism could convert compounds in SJ and enhance antioxidant activity and neuroprotective activity.
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참고문헌 (22)
참고문헌 신청
Aruoma, O. I / 1998 / Free radicals, oxidative stress and antioxidants in human health and disease / JAOCS 75:199
Coyle, J. T / 1993 / Oxidative stress, glutamate, and neurodegenerative disorders / Science 262:689
Valko, M / 2006 / Free radicals, metals and antioxidants in oxidative stressinduced cancer / Chem. Biol. Interact 160:1
Satoh, T / 1998 / Oxygen toxicity induces apoptosis in neuronal cells / Cell. Mol. Neurobiol 18:649
Smith, C. D / 1991 / Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease / Proc. Natl. Acad. Sci. U.S.A 88:10540
Coyle, J. T / 1993 / Oxidative stress, glutamate, and neurodegenerative disorders / Science 262:689
Valko, M / 2006 / Free radicals, metals and antioxidants in oxidative stressinduced cancer / Chem. Biol. Interact 160:1
Satoh, T / 1998 / Oxygen toxicity induces apoptosis in neuronal cells / Cell. Mol. Neurobiol 18:649
Smith, C. D / 1991 / Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease / Proc. Natl. Acad. Sci. U.S.A 88:10540
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