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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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FGFR3 is a member of the fibroblast growth factor receptor family which interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Accumulated evidence suggests that aberrant regulation of FGFR3 and genetic alterations are implicated in the development and progression of various cancers. Despite a high incidence of FGFR3 over-expression, no such investigation has been performed in hepatocellular carcinoma. Thus, we investigated genetic alterations of the FGFR3 gene in 73 cases of hepatocellular carcinoma by single-strand conformational polymorphism (SSCP) and sequencing. One silent mutation (A369A) was found in the extracellular domain of FGFR3, and one genetic alteration in the immunoglobulin-like III domain of FGFR3 appeared to be polymorphism. Taken together, we concluded that over-expression of FGFR3 in hepatocellular carcinoma is not associated with genetic alterations of FGFR3 gene, and we suggest that there could be another underlying mechanism of aberrant FGFR3 expression in hepatocellular carcinoma.
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참고문헌 (33)
참고문헌 신청
Song, J. / 2006 / Genetic and epigenetic alterations of the KLF6 gene in hepatocellular carcinoma / Journal of Gastroenterology and Hepatology 21:1286
Villanueva, A. / 2007 / Genomics and signaling pathways in hepatocellular carcinoma / Seminars in Liver Disease 27:55
Sahadevan, K. / 2007 / Selective overexpression of fibroblast growth factor receptors 1 and 4 in clinical prostate cancer / J. Pathol 213:82
Jemal, A. / 2011 / Global cancer statistics / CA Cancer J. Clin 61:69
Whittaker, S. / 2010 / The role of signaling pathways in the development and treatment of hepatocellular carcinoma / Oncogene 29:4989
Villanueva, A. / 2007 / Genomics and signaling pathways in hepatocellular carcinoma / Seminars in Liver Disease 27:55
Sahadevan, K. / 2007 / Selective overexpression of fibroblast growth factor receptors 1 and 4 in clinical prostate cancer / J. Pathol 213:82
Jemal, A. / 2011 / Global cancer statistics / CA Cancer J. Clin 61:69
Whittaker, S. / 2010 / The role of signaling pathways in the development and treatment of hepatocellular carcinoma / Oncogene 29:4989
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