지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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In the present study, we determined the antifungal effect of obacunone isolated from Phellodendri Cortex against Candida ablicans, a pathogenic fungus. The antifungal effect was analyzed by an in-vitro susceptibility test and in a murine model of disseminated candidiasis. Possible mechanism of the antifungal activity was also examined. Analyses of data resulting from the susceptibility test revealed that the compound inhibited C. albicans growth. At 25 ${\mu}g$ obacunone/ml, there was app. 45% reduction of CFUs (colony forming units) as compared to obacunone-untreated C. albicans yeast cells (P<0.01). In the murine model of disseminated candidiasis due to C. albicans, obacunone enhanced resistance of mice against disseminated candidiasis. During an entire period of 30-day observation, control animals all died within 14 days, whereas 60% of obacunone-treated mice survived (P<0.05). In addition, obacunone inhibited the hyphal production, a major virulence factor of C. albicans, from the blastoconidial form. Thus, obacunone appears to have antifungal activity for C. albicans infection. This may possibly be mediated by the blockage of hyphal production.
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참고문헌 (20)
참고문헌 신청
Schaberg, D. R / 1991 / Major trends in the microbial etiology of nosocomial infection / Am. J. Med 16:72S
Edwards, J. E / 1991 / Edwards, J. E. : Invasive Candida infections: evolution of a fungal pathogen / N. Engl. J. Med 324:1060
Gow, N. A / 2002 / Fungal morphogenesis and host invasion. Curr. Opin / Microbiol 5:366
Bodey, G. P / 1988 / The emergence of fungi as major hospital pathogens / J. Hosp. Infect 11:411
Sobel, J. D / 1985 / Epidemiology and pathogenesis of recurrent vulvovaginal candidiasis / Am. J. Obstet. Gynecol 152:924
Edwards, J. E / 1991 / Edwards, J. E. : Invasive Candida infections: evolution of a fungal pathogen / N. Engl. J. Med 324:1060
Gow, N. A / 2002 / Fungal morphogenesis and host invasion. Curr. Opin / Microbiol 5:366
Bodey, G. P / 1988 / The emergence of fungi as major hospital pathogens / J. Hosp. Infect 11:411
Sobel, J. D / 1985 / Epidemiology and pathogenesis of recurrent vulvovaginal candidiasis / Am. J. Obstet. Gynecol 152:924
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