지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
In this present study, we determined whether or not there is an immunoadjuvant effect of ochnaflavone, a biflavone isolated from Lonicera japonica. As an antigenic source, the cell wall (CACW) of Candida albicans, a fungal pathogen, was used. CACW consists of 95% carbohydrate (mannan). In the experiments, BALB/c mice were immunized with emersion forms of CACW combined with or without ochnaflavone (Och) in the presence of IFA containing mineral oil or CACW alone. Then, the amounts of antisera collected from these mice groups were measured by the ELISA method. Data from these experiments showed that CACW combined with Och (CACW/Och/IFA) provoked the production of antisera app. 2.2 or 5 times more than the corresponding CACW/IFA or CACW alone (CACW/DPBS), respectively, in mice (P<0.05). We further examined the immune response type induced by Och. Analysis of the values of the IgG1/IgG2a ratios obtained from IgG isotyping revealed that Och induced Th2-immunity more dominantly than Th1. This finding was confirmed by cytokine profile. CACW/Och/IFA formulation induced IL-4 (Th2-type cytokine) more than IFN${\gamma}$ (Th1-type cytokine) as compared with CACW/IFA and CACW/DPBS formulations (P<0.05). All data combined, Och appears to have an immunoadjuvant activity that may convert Th1 immunity into Th2 immunity.
목차
등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Lavigne, L. M. / 1998 / The role of recombinant murine IL-12 and INF- γ in the pathogenesis of murine systemic Candida albicans infection / J. Immunol 160:284
Herzyk, D. J. / 2001 / Immunomodulatory effects of anti-CD4 antibody in host resistance against infections and tumors in human CD4 transgenic mice / Infect. Immun 69:1032
MacLeod, M. K. / 2008 / CD4 memory T cells divide poorly in response to antigen because of their cytokine profile / Proc. Natl. Acad Sci. (USA) 23:14521
Weaver, C. T. / 2007 / IL-17 family cytokines and the expanding diversity of effector T cell lineages / Annu Rev. Immunol 25:821
Corthay, A. / 2006 / A three-cell model for activation of naïve T helper cells / Scand J. Immunol 64:93
Herzyk, D. J. / 2001 / Immunomodulatory effects of anti-CD4 antibody in host resistance against infections and tumors in human CD4 transgenic mice / Infect. Immun 69:1032
MacLeod, M. K. / 2008 / CD4 memory T cells divide poorly in response to antigen because of their cytokine profile / Proc. Natl. Acad Sci. (USA) 23:14521
Weaver, C. T. / 2007 / IL-17 family cytokines and the expanding diversity of effector T cell lineages / Annu Rev. Immunol 25:821
Corthay, A. / 2006 / A three-cell model for activation of naïve T helper cells / Scand J. Immunol 64:93
이 논문의 저자 정보
최근 본 자료
댓글(0)
0