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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Sabaek-san has been used for the treatment of inflammatory diseases derived from the cold with high fever, cough, and lung dysfunction in Korea and China. There is no study for the comparison between different solvent extracts of Sabaek-san. We made two samples, one is Sabaek-san water extract (SBSW) and the other is Sabaek-san 30% EtOH extract (SBSE). Both extracts inhibited inducible nitric oxide synthase(iNOS) protein, reduced iNOS-derived nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Also, they reduced tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) and interleukin-$1{\beta}$ (IL-$1{\beta}$) production. These anti-inflammatory effects caused by induction of heme oxygenase (HO)-1. HO-1 enzyme plays an important role of cellular anti-oxidant and anti-inflammatory systems. The induction of HO-1 is primarily regulated at the transcriptional level, and its induction by various inducers is related to the nuclear transcription factor-E2-related factor 2 (Nrf2). However, it is worth taking note that SBSE has more powerful anti-inflammatory effects than SBSW. In this study we suggest that different solvent extraction makes different therapeutic actions.
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참고문헌 (31)
참고문헌 신청
Wheeler, M. A. / 1997 / Bacterial infection induces nitric oxide synthase in human neutrophils / J. Clin. Invest 99:110
Hempel, S. L. / 1994 / Lipopolysaccharide induces prostaglandin H synthase-2 protein and mRNA in human alveolar macrophages and blood monocytes / J. Clin. Invest 93:391
Remick, D. G. / 1990 / Role of tumor necrosis factor-alpha in lipopolysaccharide-induced pathologic alterations / Am. J. Pathol 136:49
Hsu, H. Y. / 2002 / Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression / J. Biol. Chem 277:22131
Yoshimoto, T. / 1992 / High serum IL-6 level reflects susceptible status of the host to endotoxin and IL-1/tumor necrosis factor / J. Immunol 148:3596
Hempel, S. L. / 1994 / Lipopolysaccharide induces prostaglandin H synthase-2 protein and mRNA in human alveolar macrophages and blood monocytes / J. Clin. Invest 93:391
Remick, D. G. / 1990 / Role of tumor necrosis factor-alpha in lipopolysaccharide-induced pathologic alterations / Am. J. Pathol 136:49
Hsu, H. Y. / 2002 / Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression / J. Biol. Chem 277:22131
Yoshimoto, T. / 1992 / High serum IL-6 level reflects susceptible status of the host to endotoxin and IL-1/tumor necrosis factor / J. Immunol 148:3596
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