지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
The aim of present study was to investigate the possible influence and the related mechanism of Cinnamomum cassia derived-cinnamaldehyde on the inflammation or nociception. Cinnamomum cassia was referred to be treated for common cold or dyspepsia in the traditional medicine. However, there are no reports on the antinociceptive or anti-inflammatory properties of cinnamaldehyde, the primary ingredient of Cinnamomum cassia. We hypothesized that cinnamaldehyde would play a role in the modulation of inflammation or nociception evoked by carrageenan, acetic acid or heat. Male Institute of Cancer Research mice were used and the size of edema, frequency of writhing and latency of abnormal behaviors such as licking, flicking, shaking or jumping were measured and recorded. The present study was carried out to evaluate the antiinflammatory and antinociceptive effects of cinnamaldehyde. The administration of cinnamaldehyde (30 and 100 mg/kg) inhibited carrageenan-induced paw edema only at the final phase, suggesting the blockade of synthesis or release of prostaglandins. It also reduced the frequency of the acetic acid-induced writhing reflex in mice. In addition, the administration of cinnamaldehyde prolonged the latency for extraordinary reaction at the hot plate in mice. In conclusion, cinnamaldehyde has anti-inflammatory and analgesic properties and is a potential therapeutic for inflammation and nociception.
목차
등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
Schmid-Schonbein, G. W. / 2006 / Analysis of inflammation / Annu. Rev. Biomed. Eng 8:93
Brenner, P. S. / 2003 / Regulation of inflammation: A review of recent advances in anti-inflammatory strategies / Curr. Med. Chem. Anti-Inflamm. Anti-Allergy Agents 2:274
Hansson, G. K. / 2005 / Inflammation, atherosclerosis, and coronary artery disease / N. Engl. J. Med 352:1685
Merskey, H. / 1991 / The definition of pain / Eur. Psychiat 6:153
Argoff, C. E. / 2007 / The coexistence of neuropathic pain, sleep, and psychiatric disorders: novel treatment approach / Clin. J. Pain 23:15
Brenner, P. S. / 2003 / Regulation of inflammation: A review of recent advances in anti-inflammatory strategies / Curr. Med. Chem. Anti-Inflamm. Anti-Allergy Agents 2:274
Hansson, G. K. / 2005 / Inflammation, atherosclerosis, and coronary artery disease / N. Engl. J. Med 352:1685
Merskey, H. / 1991 / The definition of pain / Eur. Psychiat 6:153
Argoff, C. E. / 2007 / The coexistence of neuropathic pain, sleep, and psychiatric disorders: novel treatment approach / Clin. J. Pain 23:15
이 논문의 저자 정보
최근 본 자료
댓글(0)
0