지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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In vitro antibacterial activity of DW286 was tested against recently collected clinical isolates of Gram-positive strains by the two fold agar dilution method. In vivo activity of DW286 was also determined against systemic infections in mice caused by Staphylococcus aureus. DW286 showed 16~64-fold more potent in vitro activities than ciprofloxacin against Gram-positive bacteria. Against systemic infection model caused by two S. aureus strains, one being methicillin-susceptible and the other methicillin-resistant, DW286 ($ED_{50}s$, 0.16 mg/kg and 4.36 mg/kg, respectively) was more potent than gemifloxacin (1.37 mg/kg, 26.58 mg/kg, respectively).
목차
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참고문헌 (14)
참고문헌 신청
Levy, S. B. / 2004 / Antibacterial resistance worldwide: causes, challenges and responses / Nat. Med 10:122
Livermore, D., M. / 2004 / The need for new antibiotics / Clin. Microbiol. Infect 10:1
Wise, R. / 2011 / BSAC working party on the urgent need: Regenerating antibacterial drug discovery and development / J. Antimicrob. Chemother 66:1939
Jabes, D. / 2011 / The antibiotic R&D pipeline: an update / Curr. Opin. in Microbiol 14:564
Hooper, D. C. / 2003 / Quinolone antimicrobial agents / ASM Press
Livermore, D., M. / 2004 / The need for new antibiotics / Clin. Microbiol. Infect 10:1
Wise, R. / 2011 / BSAC working party on the urgent need: Regenerating antibacterial drug discovery and development / J. Antimicrob. Chemother 66:1939
Jabes, D. / 2011 / The antibiotic R&D pipeline: an update / Curr. Opin. in Microbiol 14:564
Hooper, D. C. / 2003 / Quinolone antimicrobial agents / ASM Press
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