지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Curcumin, of which a critical characteristic is the capacity of crossing the blood-brain barrier, has been reported to induce the expression of neuroprotective heme oxygenase (HO)-1. The aim of this study is to compare HO-1-inducing capacity and neuroprotective activity of curcumin, its demethoxy (demethoxycurcumin, DMC; bis-demethoxycurcumin, BDMC) and hydrogenated derivatives (tetrahydrocurcumin, THC) in mouse hippocampal HT22 cells. Curcumin attenuated glutamate-induced cell death through HO-1 expression. DMC lacking a methoxy group on one of the aromatic rings possessed slightly lower activity in HO-1 expression and neuroprotection than curcumin. Similarly, BDMC, which lacks two methoxy groups on both of the aromatic rings, showed less activity than curcumin. These findings suggest that the presence of methoxy groups on the aromatic ring is required to enhance neuroprotective HO-1 expression. The reduction of the diarylheptadienone chain of curcumin by hydrogen, as in THC, was accompanied by a complete loss of ability to induce HO-1 expression and neuroprotection, suggesting that the conjugated double bonds of the central seven-carbon chain of curcumin may be essential for its ability to induce neuroprotective HO-1 expression. Our findings may provide useful information for further development of neuroprotective HO-1 inducers.
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참고문헌 (18)
참고문헌 신청
Ramassamy, C / 2006 / Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets / European Journal of Pharmacology 545:51
Emerit, J. / 2004 / Neurodegenerative diseases and oxidative stress / Biomedicine & Pharmacotherapy 58:39
Wojcik, M / 2010 / A review of natural and synthetic antioxidants important for health and longevity / Current Medicinal Chemistry 17:3262
Ryter, S. W. / 2006 / Heme oxygenase-1/ carbon monoxide: from basic science to therapeutic applications / Physiological Reviews 86:583
Takeda, A / 2004 / Heme catabolism and heme oxygenase in neurodegenerative disease / Antioxidants & Redox Signaling 6:888
Emerit, J. / 2004 / Neurodegenerative diseases and oxidative stress / Biomedicine & Pharmacotherapy 58:39
Wojcik, M / 2010 / A review of natural and synthetic antioxidants important for health and longevity / Current Medicinal Chemistry 17:3262
Ryter, S. W. / 2006 / Heme oxygenase-1/ carbon monoxide: from basic science to therapeutic applications / Physiological Reviews 86:583
Takeda, A / 2004 / Heme catabolism and heme oxygenase in neurodegenerative disease / Antioxidants & Redox Signaling 6:888
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