지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Background: Since December 2010, online computerized prospective drug utilization review (pDUR) has been implemented in Korea. pDUR involves the review of each prescription before the medication is dispensed to the individual patient. The pDUR is performed electronically by Health Insurance Review & Assessment Service (HIRA), which is a Korean governmental agency, and then HIRA provides medical institutions and pharmacies with information that can be helpful to them in preventing potential drug problems such as drug/drug interactions or ingredient duplication. The aim of this study was to assess the impact of the Korean pDUR implementation on the proportion of drug-drug interactions (DDIs) using claims data from HIRA. Methods: A before-after comparison of the prevalence of DDIs between prescription was conducted, using HIRA administrative claims data of medical institution from January 2010 to December 2011. The analysis unit was the prescription issued and pairs before and after. The main outcome measures were the proportion of DDIs within- (control group) or between- physician encounters. To examine the difference, a paired t-test was applied. Results: We found that DDIs proportion between prescription decreased significantly (t=3.04, p=0.0026) after the implementation of pDUR, whereas there is no significant reduction within prescription (t=1.15, p=0.2518). With respect to the prevalence of DDIs between drug groups, the most dramatic reduction was occurred between 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and anti-fungal agents. Conclusion: It seems effective that giving a direct feedback to prescribers by a prospective DUR. Further research is needed to assess the impact of DUR to final outcomes such as hospitalization.
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참고문헌 (27)
참고문헌 신청
Bates DW / 1995 / Incidence of adverse drug events and potential adverse drug events : implications for prevention / JAMA 274(1):29~34
Kohn LT / 2001 / Institute of Medicine. To err is human: building a safer health system / Academy Press
Jha AK / 2001 / Identifying hospital admissions due to adverse drug events using a computer-based monitor / Pharmacoepidemiol Drug Saf 10(2):113~119
Ernst FR / 2001 / Drug-related morbidity and mortality: updating the cost-of-illness model / J Am Pharm Assoc 41(2):192~199
Leape LL / 1995 / Systems analysis of adverse drug events / JAMA 274(1):35~43
Kohn LT / 2001 / Institute of Medicine. To err is human: building a safer health system / Academy Press
Jha AK / 2001 / Identifying hospital admissions due to adverse drug events using a computer-based monitor / Pharmacoepidemiol Drug Saf 10(2):113~119
Ernst FR / 2001 / Drug-related morbidity and mortality: updating the cost-of-illness model / J Am Pharm Assoc 41(2):192~199
Leape LL / 1995 / Systems analysis of adverse drug events / JAMA 274(1):35~43
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