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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 212 - 219 (8page)
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Objectives : Cirsium japonicum is a traditional Korean medicine that has been used in the treatment of inflammatory diseases such as appendicitis, hepatitis, pulmonary abscess and tumor. The aim of study was to elucidate anti-migratory activity of CJP(Cirsium japonicum pharmacopuncture) through regulation of inflammatory mediators in C6 glioma cell. Methods : Nitric oxide(NO) production was determined by using nitrite assay. The cell migration was analyzed by wound-healing assay and Boyden chamber assay. The expression levels of iNOS, and protein kinase C(PKC)-${\alpha}$ were measured by western blotting assay. Results : CJP showed a significant decrease on NO production. Moreover, glioma cell migration was effectively suppressed by CJP. Furthermore, CJP inhibited the expressions of iNOS and PKC-${\alpha}$ in C6 glioma cells. Conclusions : These results suggest that CJP inhibits glioma cell migration and iNOS expression through regulation of PKC-${\alpha}$. Therefore, it is expected that CJP could be an effective agents for blocking malignant progression of glioma.
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참고문헌 (41)
참고문헌 신청
An YL / 2011 / Preparation and characterization of realgar nanoparticles and their inhibitory effect on rat glioma cells / International Journal of Nanomedicine 6:3187~3194
Westphal M / 2011 / The neurobiology of gliomas： from cell biology to the development of therapeutic approaches / Nat Rev Neurosci 12(9):495~508
Furnari FB / 2007 / Malignant astrocytic glioma: genetics, biology, and paths to treatment / Genes Dev 21(21):2683~2710
Guo G / 2013 / Oleanolic acid suppresses migration and invasion of malignant glioma cells by inactivating mapk/erk signaling pathway / PLoS ONE 8(8):e72079
Auffinger B / 2013 / MicroRNA targeting as a therapeutic strategy against glioma / Curr Mol Med 13(4):535~542
Westphal M / 2011 / The neurobiology of gliomas： from cell biology to the development of therapeutic approaches / Nat Rev Neurosci 12(9):495~508
Furnari FB / 2007 / Malignant astrocytic glioma: genetics, biology, and paths to treatment / Genes Dev 21(21):2683~2710
Guo G / 2013 / Oleanolic acid suppresses migration and invasion of malignant glioma cells by inactivating mapk/erk signaling pathway / PLoS ONE 8(8):e72079
Auffinger B / 2013 / MicroRNA targeting as a therapeutic strategy against glioma / Curr Mol Med 13(4):535~542
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