지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Coaxial dual electrospun nanofibers were designed for the sustained release of combination drugs. The nanofibers had a sheath-core structure composed of poly(ethylene oxide)/poly(D,L-lactic acid) blend in the sheath and poly(D,L-lactic acid) with drugs in the core. The properties as a carrier in a drug delivery system were analyzed using Fourier transform infrared spectrophotometry, X-ray diffractometry, scanning electron microscopy, and field emission transmission electron microscopy. The release behaviors of the combination drug of methotrexate/probucol were tested. Cumulative release amounts were proportionally increased according to the increased poly(ethylene oxide) ratio in the sheath. The initial release of probucol was approximately half that of methotrexate. In long-term release, the release rate of methotrexate decreased relatively, but that of probucol remained steady. The drug-diffusion milieu in the sheath of the coaxial nanofiber greatly affected the short- and long-term release of the drugs. The possibility of classified release control by components in combination drugs was ascertained.
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참고문헌 (41)
참고문헌 신청
J. V. Patil / 2017 / Electrospinning: A Versatile Technique for Making of 1D Growth of Nanostructured Nanofibers and Its Applications: An Experimental Approach / Appl. Surface Sci. 423:641~674
M. Liu / 2017 / Electrospun Nanofibers for Wound Healing / Mater. Sci. Eng. : C 76:1413~1423
F. Mohammadian / 2017 / Drug Loading and Delivery Using Nanofibers Scaffolds / Artif. Cells, Nanomed. and Biotechnol. 45:881~888
J. Pelipenko / 2015 / Critical Attributes of Nanofibers: Preparation, Drug Loading, and Tissue Regeneration / Int. J. Pharmaceut. 484:57~74
A. Abdal-hay / 2018 / Electrospun Biphasic Tubular Scaffold with Enhanced Mechanical Properties for Vascular Tissue Engineering / Mater. Sci. Eng.: C 82:10~18
M. Liu / 2017 / Electrospun Nanofibers for Wound Healing / Mater. Sci. Eng. : C 76:1413~1423
F. Mohammadian / 2017 / Drug Loading and Delivery Using Nanofibers Scaffolds / Artif. Cells, Nanomed. and Biotechnol. 45:881~888
J. Pelipenko / 2015 / Critical Attributes of Nanofibers: Preparation, Drug Loading, and Tissue Regeneration / Int. J. Pharmaceut. 484:57~74
A. Abdal-hay / 2018 / Electrospun Biphasic Tubular Scaffold with Enhanced Mechanical Properties for Vascular Tissue Engineering / Mater. Sci. Eng.: C 82:10~18
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