Characteristics of Cholesterol-lowering Lactobacillus casei subsp. casei strain GL-03 Isolated from Cheese

Hou, Hong-Man; Guo, Dong-Qi; Zhang, Gong-Liang; Sun, Li-Ming; Cui, Yu-Na

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자료유형: 학술저널

저자정보: Hou, Hong-Man (School of Food Science and Technology, Dalian Polytechnic University) Guo, Dong-Qi (School of Food Science and Technology, Dalian Polytechnic University) Zhang, Gong-Liang (School of Food Science and Technology, Dalian Polytechnic University) Sun, Li-Ming (School of Food Science and Technology, Dalian Polytechnic University) Cui, Yu-Na (School of Food Science and Technology, Dalian Polytechnic University)

저널정보: 한국응용생명화학회 Applied Biological Chemistry Applied Biological Chemistry 제57권 제5호

발행연도: 2014.1

수록면: 597 - 603 (7page)

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Cholesterol-lowering effect of lactic acid bacteria is well-known. In the present study, nine cholesterol-lowering Lactobacillus strains from Chinese traditional cheese, pickle, and yoghurt were screened and characterized for their potential use. The microbial contents of all strains significantly decreased at pH 1.5; however, the residual counts of Lactobacillus casei subsp. casei GL-03, L. plantarum ZP-Z, L. plantarum ZP-05, and L. brevis ZP-04 were more than $10^7CFU/mL$ after incubation for 6 h. All nine strains of Lactobacillus indicated good tolerance to bile at concentration less than 0.2% after incubation for 2 to 6 h. L. plantarum ZP-W had maximum hydrophobicity towards xylene, whereas GL-03 strain possessed maximum hydrophobicity for both hexadecane and octane. ZP-05 strain had more effective inhibitory activity against both Staphylococcus aureus and Bacillus subtilis than other eight strains. Furthermore, GL-03 strain significantly reduced cholesterol TC and TG levels in hyperlipidemia mice fed high-cholesterol diet. The growth of GL-03 strain was promoted by five kinds of Chinese herbal medicines, and the Chinese hawthorn at concentration of 0.0125% showed the highest promoting effect. These results suggest that L. casei subsp. casei GL-03 may be effective as a probiotic with cholesterol-lowering activities.

#Chinese herbal medicine #cholesterol-reduction #Lactobacillus #Lactobacillus casei subsp #casei GL-03

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