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자료유형
학술저널
저자정보
Hwang, Inkyu (Functional Materials Research Group. Korea Food Research Institute) Choi, Daewoon (Functional Materials Research Group. Korea Food Research Institute) See, Hyejeong (Functional Materials Research Group. Korea Food Research Institute) Kim, Wonyong (Department of Microbiology, College of Medicine, Chuang-Ang University) Chung, In Sik (Department of Genetic Engineering and Graduate School of Biotechnology, Kyung-Hee University) Shon, Dong-Hwa (Functional Materials Research Group. Korea Food Research Institute)
저널정보
한국응용생명화학회 Applied Biological Chemistry Applied Biological Chemistry 제56권 제1호
발행연도
2013.1
수록면
95 - 98 (4page)

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In an effort to develop a new vaccine for hepatitis A, which is mainly transmitted via contaminated foods and water, recombinant virus protein 1 (VP1) of hepatitis A virus was used as an antigen. Several adjuvants in a single or a mixed form, i.e., alum, CpG oligodeoxynucleotide, monophosphoryl lipid A (MPL), alum plus MPL, and CpG plus MPL, were also tested for their immunological properties. When their effects on the production of VP1-specific IgG relative to that of total IgG and the levels of and balance between Th1- and Th2-type cytokine productions were compared, CpG plus MPL was found to have highly beneficial effects, providing a new insight in selection of adjuvant for development of a new vaccine.

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