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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 237 - 241 (5page)
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초록· 키워드
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Exposure to ultraviolet (UV) radiation increased the cytotoxic effect of rice leaf extract on human colon carcinoma HCT-116 cells, suggesting that the production of cytotoxic compounds in rice leaves are induced by UV treatment. To identify cytotoxic agents in UV-treated rice leaves, the phenolic compound peaks prominently increased by UV treatment were isolated using reversed phase high performance liquid chromatography (HPLC). The isolated compounds were identified as N-trans-cinnamoyltyramine, N-benzoyltryptamine, and sakuranetin using NMR and mass spectrometric techniques. N-Benzoyltryptamine and sakuranetin were previously reported as rice phytoalexins, and N-trans-cinnamoyltyramine was first isolated from rice. N-Benzoyltryptamine and sakuranetin were found to inhibit the growth of HCT-116 cells with $IC_{50}$ values of $89.2{\pm}4.8$ and $68.8{\pm}5.2{\mu}g/mL$, respectively, indicating that these phytoalexins are cytotoxic agents in the UV-treated rice leaves. These results suggest that rice phytoalexins are potent anti-cancer agents and UV-treated rice leaves are valuable source for therapeutic agents.
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