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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 619 - 623 (5page)
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초록· 키워드
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Bioavailability of a nanoparticulate formulation of coenzyme $Q_{10}$ (NQ20), which has high stability in the water phase, was evaluated. The particle size was 188 nm, and the zeta potential value was between -38.8 and -44.8 mV at 4, 25, and $40^{\circ}C$ in distilled water after eight weeks storage. Bioavailability of NQ20 was compared with a commercial coenzyme $Q_{10}$ in oil and water phases as emulsified form using male Sprague-Dawley rats. After single oral administration of each coenzyme $Q_{10}$ solution, the blood of rats was collected at 0, 1, 2, 3, 4, 5, 6, 9, and 12 h, and the concentrations of coenzyme $Q_{10}$ were analyzed by high performance liquid chromatography. The plasma coenzyme $Q_{10}$ levels at 1, 2, and 12 h were significantly higher when the rats were administered NQ20 compared to coenzyme $Q_{10}$ in oil. The maximum plasma concentration ($C_{max}$) and area under the concentration-time curve (AUC) values for NQ20 were $1.10{\pm}0.18$ and $5.92{\pm}1.11mM{\cdot}h/mL$, whereas the $C_{max}$ and AUC of coenzyme $Q_{10}$ in oil were $0.79{\pm}0.07$ and $5.30{\pm}0.62mM{\cdot}h/mL$, respectively(p>0.05). Due to high absorbability and small particle size, NQ20 was found to have similar bioavailability to commercial coenzyme $Q_{10}$ in the oil phase. Results indicate applicability of NQ20 in the food industry, particularly in beverages.
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