지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 67 - 80 (14page)
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Objectives : We investigated the effects of Ingecheonggeumdan(ICD) on body weight and examined whether blood lipid levels and visceral fat are inhibited by it in high fat diet-fed obese male mice. Methods : 8 weeks old, high fat diet-fed obese male mice were divided into 6 groups: C57BL/6N normal, control, ICD-1(150mg/kg), ICD-2(300mg/kg), ICD-3(600mg/kg) and orlistat(10mg/kg). After mice were treated with ICD and orlistat for 8 weeks, we measured body weight gain, food intake, feeding efficiency ratio, fat weight, plasma leptin and lipid levels. We also performed histological analysis for liver and fat on the mice. Results : Compared with controls, ICD and orlistat-treated mice had lower body weight gain and adipose tissue weight, the magnitudes of which were prominent in ICD-3. Compared with controls, ICD and orlistat-treated mice had lower blood leptin levels, the magnitude of which was prominent in ICD-3. Compared with controls, ICD and orlistat-treated mice had higher blood HDL-cholesterol and lower blood plasma LDL-cholesterol, free fatty acid and triglyceride levels, the magnitudes of which were prominent in ICD-3. Blood plasma AST and ALT concentrations were not changed by ICD and orlistat, indicating ICD and orlistat do not show any toxic effects. Consistent with their effects on body weight gain, the size of adipocytes and hepatic lipid accumulation were significantly decreased by ICD and orlistat. Conclusions : These results demonstrate that ICD and orlistat effectively reduce body weight gain, blood plasma LDL-cholesterol, free fatty acid and triglyceride levels and improves abdominal fat, the magnitudes of which were prominent in ICD-3.
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참고문헌 (9)
참고문헌 신청
Folsom AR / 1994 / Relation of carotid artery wall thickness to diabetes mellitus, fasting glucose and insulin, body size, and physical activity. Atherosclerosis Risk in Communities(ARIC) Study Investigators / Stroke 25(1):66~73
Abate N / 2000 / Obesity and cardiovascular disease. Pathogenetic role of the metabolic syndrome and therapeutic implications / J Diabetes Complications 14(3):154~174
Folsom AR / 2000 / Associations of general and abdominal obesity with multiple health outcomes in older women: the Iowa Women's Health Study / Arch Intern Med 160(14):2117~2128
Manson JE / 1990 / A prospective study of obesity and risk of coronary heart disease in women / N Engl J Med 322(13):882~889
DeFronzo RA / 1988 / Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM / Diabetes 37(6):667~687
Abate N / 2000 / Obesity and cardiovascular disease. Pathogenetic role of the metabolic syndrome and therapeutic implications / J Diabetes Complications 14(3):154~174
Folsom AR / 2000 / Associations of general and abdominal obesity with multiple health outcomes in older women: the Iowa Women's Health Study / Arch Intern Med 160(14):2117~2128
Manson JE / 1990 / A prospective study of obesity and risk of coronary heart disease in women / N Engl J Med 322(13):882~889
DeFronzo RA / 1988 / Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM / Diabetes 37(6):667~687
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