지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 219 - 231 (13page)
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Objectives : This study was designed to determine the effects of the GGEx18 ethyl acetate fraction(EF) on body weight gain, feeding efficiency ratio, and obesity-related factors in plasma as well as histology of liver and adipose tissues using high fat diet-fed male C57BL/6N obese mice. Methods : 8 weeks old, high fat diet-fed obese male mice were divided into 5 groups: C57BL/6N normal, control, EF(1), EF(2) and EF(3). After mice were treated with EF for 9 weeks, we measured body weight gain, food intake, feeding efficiency ratio, fat weight, plasma leptin and lipid levels. We also analysed histology of liver and adipose tissues on high fat diet-fed male C57BL/6N obese mice. Results : Compared with control, EF-treated mice had significantly lower body weight gain and feeding efficiency ratio. Consistent with the effects on body weight gain, EF significantly decreased the adipose tissue weight compared with control. Consistent with the effects on feeding efficiency ratio, EF significantly decreased plasma leptin concentrations compared with control. EF reduced the size of adipocytes as well as hepatic lipid accumulation compared with control. EF seems to be safe since not only the plasma levels of ALT and AST are within the normal range, but also EF did not show any toxic effects on organs. EF(3) was most effective among EF(1), EF(2), and EF(3) at doses of 25, 50, and 100 mg/kg, respectively. Conclusions : These results demonstrate that EF effectively reduces body weight gain, feeding efficiency ratio in high fat diet-fed obese mice, leading to the modulation of obesity. In addition, EF decreases the size of adipocytes and improves plasma lipids and controls hepatic lipid accumulation, suggesting that EF may act as a therapeutic agent for obesity.
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참고문헌 (4)
참고문헌 신청
Speakman JR / 2003 / Physical activity and resting metabolic rate / Proc Nutr Soc 62(3):621~634
김도경 / 2005 / 비만 여성에 있어 안정시 대사량과 최대산소섭취량과의 관련성 / 대한스포츠의학회지 23(2):131~136
Park HS / 2000 / Pathophysiology of obesity and energy control for obesity treatment / J Korean Acad Fam Med 22(8):1287~1295
Garrido-Polonio C / 2004 / Thermally oxidised sunflower-seed oil increases liver and serum peroxidation and modifies lipoprotein composition in rats / Br J Nutr 92(2):257~265
김도경 / 2005 / 비만 여성에 있어 안정시 대사량과 최대산소섭취량과의 관련성 / 대한스포츠의학회지 23(2):131~136
Park HS / 2000 / Pathophysiology of obesity and energy control for obesity treatment / J Korean Acad Fam Med 22(8):1287~1295
Garrido-Polonio C / 2004 / Thermally oxidised sunflower-seed oil increases liver and serum peroxidation and modifies lipoprotein composition in rats / Br J Nutr 92(2):257~265
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