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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 471 - 481 (11page)
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Objectives : Noemyeong-san (NMS) is a novel herbal prescription composed of five oriental medicinal herbs including Prunellae Spica, Betulae Cortex, Foeniculi Fructus, Asiasari Radix, and Clematidis Radix for treating Alzheimer's disease. In the present study, we investigated the effects and molecular mechanisms of NMS on BV2 microglia to evaluate the potential action of this formula for preventing or treating neurodegenerative disease such as Alzheimer's disease. Methods : To determine the cytotoxicity of NMS on BV2 microglia, the MTT assay was performed. The effects of NMS on lipopolysaccharide (LPS)-stimulated BV2 microglia were determined with a nitric oxide (NO) assay and western blots for inflammatory mediator-related proteins, mitogen activated protein kinases (MAPKs), nuclear factor kappa B (NF-${\kappa}B$) pathway-related proteins, and heme oxygenase-1 (HO-1). Result : NMS inhibited induction of iNOS and COX-2 as well as NO production without affecting the cell viability in LPS-stimulated BV2 microglia. NMS also suppressed activation of ERK and p38 MAPK among main kinases of MAPKs as well as NF-${\kappa}B$ by LPS stimulation. Furthermore, NMS dose-dependently induced the expression of HO-1 and the inhibitory effect of NMS on the production of NO were blocked by pretreatment with an HO-1 inhibitor, Snpp. Conclusions : These results demonstrate that NMS has potent anti-neuroinflammatory effect on the LPS-stimulated microglia. These findings provide evidences for NMS to be considered as a new prescription for preventing or treating neurodegenerative disease such as Alzheimer's disease.
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참고문헌 (18)
참고문헌 신청
김정란 / 2015 / 신경아교세포와 알츠하이머 병 / 생물정신의학 22(2):40~49
Olmos-Alonso A / 2016 / Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer'slike pathology / Brain 139(Pt 3):891~907
권용주 / 2010 / 치매의 한약물 치료에 대한 체계적 임상논문 고찰 - 국내문헌을 중심으로 - / 동의신경정신과학회지 21(4):151~161
김우영 / 2011 / 한의학의 치매관련 임상연구 동향분석과 제안 / 한국한의학연구원논문집 17(2):39~46
정효창 / 2004 / 공진단이 알츠하이머형 치매 환자에게 미치는 영향 / 동의신경정신과학회지 15(2):141~148
Olmos-Alonso A / 2016 / Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer'slike pathology / Brain 139(Pt 3):891~907
권용주 / 2010 / 치매의 한약물 치료에 대한 체계적 임상논문 고찰 - 국내문헌을 중심으로 - / 동의신경정신과학회지 21(4):151~161
김우영 / 2011 / 한의학의 치매관련 임상연구 동향분석과 제안 / 한국한의학연구원논문집 17(2):39~46
정효창 / 2004 / 공진단이 알츠하이머형 치매 환자에게 미치는 영향 / 동의신경정신과학회지 15(2):141~148
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