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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 145 - 160 (16page)
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초록· 키워드
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Objectives : Rehmannia glutinosa has been used extensively in Korean traditional medicine. Although thorough clinical trials are lacking, Various pharmacological actions for Rehmannia glutinosa has been identified newly using animal models. In addition, it was reported that reactive intermediates, potentially causing toxic effects, was isolated from one of components in Rehmannia glutinosa. In this article, it is purposed for explanation and introduction of new studies for Rehmannia glutinosa in terms of pharmacological action and toxicology. Methods : New studies for Rehmannia glutinosa were reviewed and summarized in terms of pharmacological action and toxicity. Results and Conclusions : Rhmannia glutinosa and its components including iridoids, saccharides, as well as amino acid, showed a variety of pharmacological actions on the blood system, immune system, endocrine system, cardiovascular system and the nervous system. In addition, it was identified that aucubin, one of major components of Rhmannia glutinosa was biotransformed to reactive intermediates by ${\beta}$-glycosidase and acid-hydrolysis, resulting in forming aucubigenin- albumin adduct. Even if a lot of new pharmacological actions has been identified, it should be considered for Rhmannia glutinosa to contain the material producing reactive intermediates which may induce the side effects.
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참고문헌 (41)
참고문헌 신청
www.rain-tree.com/rehmannia
Wang, HG / 1997 / A study on catalpol content changes in Rehmannia glutinosa(Gaertn.) Libosch. under certain conditions / China Journal of Chinese Materia Medica 22:408~409
Ru-Xue Zhang / 2008 / Rehmannia glutinosa: Review of botany, chemistry and pharmacology / Journal of Ethnopharmacology 117:199~214
Bartholomaeus, A / 1995 / Inhibition of P-450 by aucubin: is the biological activity of aucubin due to its glutaraldehyde-like aglycone / Toxicol. Lett 80:75~83
Oshio, H. / 1982 / Iridoid glycosides of Rehmannia glutinosa / Phytochemistry 21:133~138
Wang, HG / 1997 / A study on catalpol content changes in Rehmannia glutinosa(Gaertn.) Libosch. under certain conditions / China Journal of Chinese Materia Medica 22:408~409
Ru-Xue Zhang / 2008 / Rehmannia glutinosa: Review of botany, chemistry and pharmacology / Journal of Ethnopharmacology 117:199~214
Bartholomaeus, A / 1995 / Inhibition of P-450 by aucubin: is the biological activity of aucubin due to its glutaraldehyde-like aglycone / Toxicol. Lett 80:75~83
Oshio, H. / 1982 / Iridoid glycosides of Rehmannia glutinosa / Phytochemistry 21:133~138
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