지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 7 - 13 (7page)
이용수
초록· 키워드
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Objectives : Chronic mild stress (CMS) model is currently recognized as a better animal model of depression. The purpose of this study was to investigate the antidepressant-like effects of the Nelumbo nucifera leave extract using CMS model. Methods : The antidepressant-like effects of Nelumbo nucifera leaves extract was determined by using animal models of depression. Male ICR mice were divided into four groups: saline-treated normal, without CMS; saline-treated stress control; CMS+ Imipramine(20mg/kg); CMS+Nelumbo nucifera leaves extract(200mg/kg). All mice except the normal group exposed an unpredicted sequence of chronic mild stressors for 5 weeks. The behavior of mice were detected by sucrose preference test, forced swim test and tail suspension test. Then concentration of corticosterone in serum was detected by enzyme immunoassay. Results : Nelumbo nucifera leaves extract administration by daily gavage from the 3rd week exhibited an antidepressant-like effect on CMS-induced depression in mice. Nelumbo nucifera leaves extract administration at dose of 200 mg/kg significantly increased the sucrose consumption, and decreased the immobility durations in forced swim test and tail suspension test. Furthermore the corticosterone level decreased than control group. Conclusions : Chronic mild stress can affect mouse behavior and corticosterone level and cause depression. The present experiments not only further confirm the antidepressant-like effects of Nelumbo nucifera leaves extract in the sucrose preference test, forced swimming test and tail suspension test, but also the improving effects of Nelumbo nucifera leaves extract on the depression-like symptoms in the CMS model. Nelumbo nucifera leaves extract has the antagonism on CMS and produce antidepressive effects.
목차
등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Kessler RC / 1994 / Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey / Arch Gen Psychiatry 51:8~19
Kim JH / 2007 / Antidepressant-like effects of Albizzia julibrissin in mice: involvement of the 5-HT1A receptor system / Pharmacol Biochem Behav 87:41~47
Czeh B / 2001 / Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine / Proc Natl Acad Sci USA 98(22):12796~12801
Gould E / 1997 / Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation / J Neurosci 17(7):2492~2498
Garcia R / 2002 / Stress, metaplasticity, and antidepressants / Curr Mol Med 2(7):629~638
Kim JH / 2007 / Antidepressant-like effects of Albizzia julibrissin in mice: involvement of the 5-HT1A receptor system / Pharmacol Biochem Behav 87:41~47
Czeh B / 2001 / Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine / Proc Natl Acad Sci USA 98(22):12796~12801
Gould E / 1997 / Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation / J Neurosci 17(7):2492~2498
Garcia R / 2002 / Stress, metaplasticity, and antidepressants / Curr Mol Med 2(7):629~638
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