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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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이 논문의 연구 히스토리 (5)
2014
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Objectives : The root bark of Morus alba L. (Mori Cortex Radidus; MCR) has been traditionally used to reduce heat from the lungs, soothe asthma, and edema and to promote urination. In this study, we investigated the effect of MCR ethanol extract on ovalbumin (OVA)-induced allergic asthma in mice. Methods : Mice were sensitized at day 0, 7 and 14 with 0.2% OVA and then airway challenged at day 21, 23, 25, 27 and 29 to induce allergic asthma. MCR extracts at doses of 50 and 100 mg/kg body weight (bw) were orally administered during OVA challenge once per a day. The levels of allergic mediators such as histamine, OVA-specific IgE, IFN-${\gamma}$ and IL-4 were measured in the sera of mice by ELISA. The histopathological change of lung tissues was observed with hematoxylin and eosin (H&E) staining. Results : MCR extract significantly decreased not only the serum levels of histamine, OVA-specific IgE, and IL-4 compared with those of OVA control group, but significantly increased the serum level of IFN-${\gamma}$. In H&E staining, MCR extract inhibited the infiltration of inflammatory cells and bronchiolar damage with epithelial thickening in lung tissues of OVA-induced asthma mice. Conclusions : These results indicate that MCR extract inhibits lung damage by asthma through regulating the allergic immune response, suggesting that MCR may be used as a useful agent for the treatment of allergic asthma.
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참고문헌 (29)
참고문헌 신청
Cause of death Korean Statistical Information Center / 2012 / Statistics Korea :6~7
World health organization. Asthma
Statistics korea / Classifieds of disease patients
Ishmae FT / 2011 / The inflammatory response in the pathogenesis of asthma / J Am Osteopath Assoc 111(11):11~17
Sang Heon Cho / 2006 / The Current Status of Asthma in Korea / Journal of Korean Medical Science 21(2):181~187
World health organization. Asthma
Statistics korea / Classifieds of disease patients
Ishmae FT / 2011 / The inflammatory response in the pathogenesis of asthma / J Am Osteopath Assoc 111(11):11~17
Sang Heon Cho / 2006 / The Current Status of Asthma in Korea / Journal of Korean Medical Science 21(2):181~187
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