지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 99 - 105 (7page)
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Objectives : Korean red ginseng and Morus alba L. are used as a traditional treatment for diabetes. This study was designed to elucidate whether combination with Korean red ginseng and Morus alba L. (MPM) ameliorates metabolic syndrome in fructose-fed rats. Methods : Animals were divided into four groups; Control receiving tap water, fructose-fed, rosiglitazone-treated fructose-fed rats, and MPM-treated fructose-fed rats both receiving supplemented with 60% fructose (n=10). The MPM or rosiglitazone groups initially received a high-fructose (HF) diet alone for 8 weeks, with supplementation with MPM or rosiglitazone occurring during the final 6 weeks. Results : MPM and rosiglitazone, synthetic $PPAR{\gamma}$ agonist, treatment significantly prevented the increase in fasting serum glucose, leptin, triglyceride, and low density lipoprotein in the HF group when comparing with the control group. MPM and rosiglitazone also led to an increase in high density lipoprotein level in the HF group. The administration of MPM and rosiglitazone prevented the development of the metabolic disturbances such as impaired glucose tolerance, and blood pressure. MPM suppressed increased expressions of endothelin-1 (ET-1) in HF rat aorta. In addition, MPM significantly increased IR-${\beta}$ and PPAR-${\gamma}$ expression in muscle. Conclusions : Based on these results, we suggest that the administration of MPM improves metabolic syndrome through the alteration in lipid profiles and suppression of insulin resistant and blood pressure.
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참고문헌 (31)
참고문헌 신청
Georg P. / 2000 / Lipids and diabetes / J Clin Basic Cardiol 3:159~162
Chaturvedi P. / 2004 / Effect of Momordica charantia on lipid profile and oral glucose tolerance in diabetic rats / Phytother Res 18:954~956
Kuroe A. / 2003 / Impaired β-cell function and insulin sensitivity in Japanese subjects with normal glucose tolerance / Diabetes Res Clin Pract 59:71~77
International Diabetes Federation / Diabetes Atlas, 2nd ed
Yoon KH. / 200611 / Epidemic obesity and type 2 diabetes in Asia / LANCET 368:1681~1688
Chaturvedi P. / 2004 / Effect of Momordica charantia on lipid profile and oral glucose tolerance in diabetic rats / Phytother Res 18:954~956
Kuroe A. / 2003 / Impaired β-cell function and insulin sensitivity in Japanese subjects with normal glucose tolerance / Diabetes Res Clin Pract 59:71~77
International Diabetes Federation / Diabetes Atlas, 2nd ed
Yoon KH. / 200611 / Epidemic obesity and type 2 diabetes in Asia / LANCET 368:1681~1688
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