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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 167 - 182 (16page)
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초록· 키워드
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Korean Panax ginseng C. A. Meyer (P. ginseng) is a well-known and one of the most important tonic herbs used in traditional Korean medicine. The pharmacological effects of P. ginseng have been reported by many researchers. Nevertheless, little is known between the mechanism of action and the active compounds. In this study, we performed a comprehensive proteomic analysis and protein categorization in order to understand the physiological characteristics of the major components in the adventitious roots of P. ginseng. Whole proteins extracted from the cultured adventitious roots of P. ginseng were separated by two-dimensional polyacrylamide gel electrophoresis (2-DE). Among the 1000 spots which were detected by silver staining, 113 spots were labeled and identified by matrix-assisted laser desorption/ionization-time of flight-mass spectrometry (MALDI-TOF MS). Our results showed that 40 proteins were identified among the 113 spots, with a hit ratio of 35.3%. A number of proteins identified on the 2-DE gels (30%; 16 spots) were involved in energy metabolism. These proteomic data will be helpful to better understand the physiological and pharmacological effects of P. ginseng.
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참고문헌 (29)
참고문헌 신청
Attele, A. S. / 1999 / Ginseng pharmacology: multiple constituents and multiple actions / Biochem Pharmacol 58(11):1685~1693
Bowler, M. W. / 2006 / How azide inhibits ATP hydrolysis by the F-ATPases / Proc Natl Acad Sci U S A 103(23):8646~8649
Gorg, A. / 2000 / The current state of two-dimensional electrophoresis with immobilized pH gradients / Electrophoresis 21(6):1037~1053
Hartl, F. U. / 2002 / Molecular chaperones in the cytosol: from nascent chain to folded protein / Science 295(5561):1852~1858
Hochstrasser, D. F. / 2002 / Proteomics and its trends facing nature’s complexity / Proteomics 2(7):807~812
Bowler, M. W. / 2006 / How azide inhibits ATP hydrolysis by the F-ATPases / Proc Natl Acad Sci U S A 103(23):8646~8649
Gorg, A. / 2000 / The current state of two-dimensional electrophoresis with immobilized pH gradients / Electrophoresis 21(6):1037~1053
Hartl, F. U. / 2002 / Molecular chaperones in the cytosol: from nascent chain to folded protein / Science 295(5561):1852~1858
Hochstrasser, D. F. / 2002 / Proteomics and its trends facing nature’s complexity / Proteomics 2(7):807~812
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