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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 356 - 362 (7page)
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Allergic diseases have increased rapidly over the past decades, affecting an estimated 20~30% of the population in developed countries. In this study, we investigated whether or not a typical costal sand dune plant Carex pumila (CPE) suppresses the activation of mast cells and IgE-mediated allergic response in vitro and in vivo. As the results, the extract of Carex pumila inhibited antigen-stimulated degranulation in RBL-2H3 cells and Bone marrow-derived mast cells (BMMCs), and IgE-mediated passive cutaneous anaphylaxis (PCA) in mice. CPE also suppressed the production of pro-inflammatory cytokines, TNF-${\alpha}$ and IL-4, in antigen-stimulated mast cells. As its mechanism of action, CPE inhibited the activation of Syk in $Fc{\varepsilon}RI$-mediated signalling pathway, and that of LAT, a downstream adaptor molecule of Syk, in a dose-dependent manner. CPE also suppressed the activation of mitogen-activated protein (MAP) kinases, p38, ERK1/2, JNK, and Akt. Altogether, CPE inhibited mast cell activation and IgE-mediated allergic response by antigen through suppressing the activation of Syk. These results suggest that CPE may be useful for the treatment of allergic diseases.
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참고문헌 (18)
참고문헌 신청
Ebo D.G. / 2001 / IgE-mediated food allergyextensive review of the literature / Acta Clin Belg 56:234~247
Alma J. N. / 2008 / Mechanisms of allergy and asthma / Eur J Pharmacol 585:354~360
Toshio T / 2012 / Efficacy of Flavonoids for Patients with Japanese Cedar Pollinosis / Current Insights in Pollen. Allergens :103~122
Galli, S. J. / 1993 / New concepts about the mast cells / New Eng. J. Med 328:257~270
Paolini R. / 1991 / Phosphorylation and dephosphorylation of the high-affinity receptor for immunoglobulin E immediately after receptor engantigenement and disengantigenement / Nature 353:855~858
Alma J. N. / 2008 / Mechanisms of allergy and asthma / Eur J Pharmacol 585:354~360
Toshio T / 2012 / Efficacy of Flavonoids for Patients with Japanese Cedar Pollinosis / Current Insights in Pollen. Allergens :103~122
Galli, S. J. / 1993 / New concepts about the mast cells / New Eng. J. Med 328:257~270
Paolini R. / 1991 / Phosphorylation and dephosphorylation of the high-affinity receptor for immunoglobulin E immediately after receptor engantigenement and disengantigenement / Nature 353:855~858
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