지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.99 No.3
- 발행연도
- 2020.9
- 수록면
- 180 - 187 (8page)
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Purpose: Tenofovir disoproxil fumarate is accepted as an effective and tolerable drug for treatment of HBV, similar to entecavir. However, there are some concerns about the nephrotoxicity of tenofovir. The aim of this study is to compare the renal-function change of liver recipients who received tenofovir or entecavir for HBV.
Methods: Among 468 patients with HBV who underwent liver transplantation at Samsung Medical Center between January 2008 and December 2015, the patients treated with tenofovir (n = 39) or entecavir (n = 429) were reviewed retrospectively. Baseline characteristics and renal-function change after 1 month, 1 year, and 2 years were compared. Propensity-score matching was performed for 37 patients using tenofovir and 132 patients using entecavir. We also analyzed risk factors of renal dysfunction.
Results: Age, preoperative creatinine, estimated glomerular filtration rate (e-GFR), and hepatic encephalopathy score showed statistical difference between the tenofovir and entecavir groups. The proportion of patients with ‘decreased renal function (e-GFR < 60 mL/min/1.73 m²)’ was higher in the tenofovir group than in the entecavir group (33.3% vs. 12.4% at postoperative one year, P < 0.005). After propensity-score matching, there was no statistical difference in preoperative characteristics. Postoperative 1-, 2-, and 3-year e-GFR and creatinine showed no statistical difference in either group. On multivariate analysis, only preoperative high e-GFR showed a protective effect on renal-function change (odds ratio, 0.97; P < 0.001), and there was no aggravating factor.
Conclusion: Tenofovir disoproxil fumarate does not induce renal dysfunction in liver-transplanted patients with HBV more than does entecavir
Methods: Among 468 patients with HBV who underwent liver transplantation at Samsung Medical Center between January 2008 and December 2015, the patients treated with tenofovir (n = 39) or entecavir (n = 429) were reviewed retrospectively. Baseline characteristics and renal-function change after 1 month, 1 year, and 2 years were compared. Propensity-score matching was performed for 37 patients using tenofovir and 132 patients using entecavir. We also analyzed risk factors of renal dysfunction.
Results: Age, preoperative creatinine, estimated glomerular filtration rate (e-GFR), and hepatic encephalopathy score showed statistical difference between the tenofovir and entecavir groups. The proportion of patients with ‘decreased renal function (e-GFR < 60 mL/min/1.73 m²)’ was higher in the tenofovir group than in the entecavir group (33.3% vs. 12.4% at postoperative one year, P < 0.005). After propensity-score matching, there was no statistical difference in preoperative characteristics. Postoperative 1-, 2-, and 3-year e-GFR and creatinine showed no statistical difference in either group. On multivariate analysis, only preoperative high e-GFR showed a protective effect on renal-function change (odds ratio, 0.97; P < 0.001), and there was no aggravating factor.
Conclusion: Tenofovir disoproxil fumarate does not induce renal dysfunction in liver-transplanted patients with HBV more than does entecavir
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (20)
참고문헌 신청
Bong Jun Kwak / 2018 / Clinical outcome of 1,000 consecutive cases of liver transplantation: a single center experience / Annals of Surgical Treatment and Research 95(5):267~277
Sriprayoon T / 2017 / Efficacy and safety of entecavir versus tenofovir treatment in chronic hepatitis B patients : a randomized controlled trial / Hepatol Res 47:E161~E168
Gara N / 2012 / Renal tubular dysfunction during long-term adefovir or tenofovir therapy in chronic hepatitis B / Aliment Pharmacol Ther 35:1317~1325
Pawarode A / 2003 / Independent risk factors and natural history of renal dysfunction in liver transplant recipients / Liver Transpl 9:741~747
Levey AS / 2003 / National Kidney Foundation practice guidelines for chronic kidney disease : evaluation, classification, and stratification / Ann Intern Med 139:137~147
Sriprayoon T / 2017 / Efficacy and safety of entecavir versus tenofovir treatment in chronic hepatitis B patients : a randomized controlled trial / Hepatol Res 47:E161~E168
Gara N / 2012 / Renal tubular dysfunction during long-term adefovir or tenofovir therapy in chronic hepatitis B / Aliment Pharmacol Ther 35:1317~1325
Pawarode A / 2003 / Independent risk factors and natural history of renal dysfunction in liver transplant recipients / Liver Transpl 9:741~747
Levey AS / 2003 / National Kidney Foundation practice guidelines for chronic kidney disease : evaluation, classification, and stratification / Ann Intern Med 139:137~147
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