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학술저널
저자정보
Rao, Bhattiprolu Kesava (Department of Chemistry, Nagarjuna University) Kawase, Masami (Faculty of Pharmaceutical Sciences, Josai University) Tanaka, Toru (Faculty of Pharmaceutical Sciences, Josai University) Tani, Satoru (Faculty of Pharmaceutical Sciences, Josai University) Motohashi, Noboru (Meiji Pharmaceutical University) Satoh, Kazue (School of Medicine, Showa University) Sakagami, Hiroshi (Department of Dental Pharmacology, Meikai University School of Dentistry) Terakubo, Shigemi (Department of Microbiology, St. Marianna University School of Medicine) Nakashima, Hideki (Department of Microbiology, St. Marianna University School of Medicine) Wolfard, Krisztina (Faculty of Medicine, Institute of Medical Microbiology, Albert Szent-Gyorgyi Medical Centrum, University of Szeged) Molnar, Joseph (Faculty of Medicine, Institute of Medical Microbiology, Albert Szent-Gyorgyi Medical Centrum, University of Szeged)
저널정보
경희한의학연구센터 Oriental pharmacy and experimental medicine Oriental pharmacy and experimental medicine 제4권 제3호
발행연도
2004.1
수록면
179 - 185 (7page)

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The ethanol extract of Indigofera cordifolia was studied for in vivo gastroprotective activity, cytotoxic activity against oral tumor and normal cells, multidrug resistance (MDR) reversal activity, anti-human immunodeficiency virus (HIV) activity and radical scavenging activity. The extract of I. cordifolia showed potent gastric mucosal protective activity against stomach injury induced by HCl/EtOH solution. However, the gastroprotective activity could not be related to the radical mechanism, because the extract weakly scavenged both OH radical and $O_2*^-$. The extract also showed promising levels of MDR-reversing activity. This study demonstrates the tumor-specific cytotoxic action of the plant extract. However, the extract had no anti-HIV activity. From above results, the study suggests the medicinal importance of I. cordiforia extract.

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