지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제16권 제4호
- 발행연도
- 1993.1
- 수록면
- 259 - 264 (6page)
이용수
초록· 키워드
오류제보하기
Three cell lines, CHO, L929 and B16 which are non-tumorigenic and cancer cells, respectively, were first tested for their survival in the presence of radioprotective ginseng protein fraction(GPF0. The influence of three radioprotectors-CPF, cysteamine, and 1-Methyl-2-bis[(2-methylthio)vinyl] quinolinium iodide (MVQI) on DNA repair capacity of UV damaged cells survival test, the GPF showed higher cytotoxicity in L929 and B16 than in CHO cells. However, the degree of cell killing was also investigated by measuring $^3H$-thymidine incorporation of PUVA treated cells. In cell survival test, the GPF showed higher cytotoxicity in L929 and B16 than in CHO cells. However, the degree of cell killing was not high enough to consider it as an antitumorigenic agent. Variable results were obtained in the effects on DNA repair capacity depending on the protectors and cell lines used. In pretreatment, the presence of GPF and MVOI brought about a sinificant increase in the capacity in both CHO and B16 cells. However, in L929, the enhancing effect was not shown. In all three cell lines, cysteamine showed lower repair capacity than control, suggesting the primary damage reduction in stronger enhancing effects in L929 and B16 cells, while it was weaker in CHO cells. Here also cystemine hsowed a very little or no increase in the capacity in all three cell lines. These results demonstrate that GPF has mild cytotoxicity in tumorignic cells and that GPF and MVQI enhance DNA repair capacity of UV damaged cells, whether they are tumorigenic or not. On the other hand, cysteamine shows only damage reduction effect. Celles of different genetic origin seem to give different responses to the modifier and different modifiers may possibly work by different mechanisms.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
항 방사선 인삼단백분획의 DNA수복능력 증진효과
약학회지
1992 .01
-
감마방사선에 의한 암세포의 세포손상에 관한 연구
대한방사선협회지
2004 .01
-
Differences in Their Proliferation and Differentiation between B-1 and B-2 Cell
Immune Network
2006 .03
-
Expression of Hepatitis B Virus X Protein in Hepatocytes Suppresses CD8+ T Cell Activity
Immune Network
2010 .08
-
DNA 염기손상 치유유전자의 변이와 두경부암 발생 위험성
대한구강악안면외과학회지
2008 .01
-
Immune Correlates of Resistance to Trichinella spiralis Reinfection in Mice
Parasites, Hosts and Diseases
2016 .10
-
Clonal Expansion of Allergen-specific CD4+ T Cell in the Lung in the Absence of Lymph Nodes
Immune Network
2017 .06
-
Characterization of Excision repair genes related to damaged DNA repair from eukaryotic cells
한국환경성돌연변이·발암원학회지
1997 .03
-
Regulation of Th2 Cell Immunity by Dendritic Cells
Immune Network
2016 .02
-
Cancer Cell-Lines and Normal Kidney Cells
대한약학회 학술대회
2001 .01
-
IL-17-Producing Cells in Tumor Immunity: Friends or Foes?
Immune Network
2020 .02
-
Targeting Cell-Cell and Cell-Matrix Interactions and Its Therapeutic Applications
대한약학회 학술대회
2003 .01
-
Regulatory T Cells in B Cell Follicles
Immune Network
2014 .10
-
6'-O-Galloylpaeoniflorin Protects Human Keratinocytes Against Oxidative Stress-Induced Cell Damage
Biomolecules & Therapeutics(구 응용약물학회지)
2013 .01
-
Cytotoxicity of natural killer cells co-cultured with γ-irradiatedor mitomycin C-treated feeder cells
예방수의학회지
2020 .01
-
How to start with cell line?
대한외과학회 학술대회 초록집
2016 .11
-
혈구의 변형성이 Cell-migration과 Cell-free Layer에 미치는 영향
순환기질환의공학회 학술대회
2005 .01
-
加味大黃膏의 멜라닌세포 활성억제가 자외선 조사로 인한 피부 손상 완화에 미치는 영향
한방안이비인후피부과학회지
2007 .01
-
Cannabidiol Induces Cytotoxicity and Cell Death via Apoptotic Pathway in Cancer Cell Lines
Biomolecules & Therapeutics(구 응용약물학회지)
2008 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0