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자료유형
학술저널
저자정보
Han, Seong-Rok (Departments of Neurosurgery, Ilsan Paik Hospital, College of Medicine, Inje University) Yee, Gi-Taek (Departments of Neurosurgery, Ilsan Paik Hospital, College of Medicine, Inje University) Choi, Chan-Young (Departments of Neurosurgery, Ilsan Paik Hospital, College of Medicine, Inje University) Sohn, Moon-Jun (Departments of Neurosurgery, Ilsan Paik Hospital, College of Medicine, Inje University) Lee, Dong-Joon (Departments of Neurosurgery, Ilsan Paik Hospital, College of Medicine, Inje University) Whang, Choong-Jin (Departments of Neurosurgery, Ilsan Paik Hospital, College of Medicine, Inje University)
저널정보
대한신경외과학회 대한신경외과학회지 대한신경외과학회지 제39권 제6호
발행연도
2006.1
수록면
409 - 412 (4page)

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Objective : Primary central nervous system lymphoma[PCNSL] is a non-Hodgkin's lymphoma arising in the central nervous system. Combined chemotherapy and radiation therapy is the standard treatment for PCNSL. However, treatment induced neurotoxicity is a major problem especially in elderly patients. Methods : From May 2001 to April 2004, elderly five patients with PCNSL confirmed via pathological examination were underwent Novalis radiosurgery in authors' institution, who were investigated retrospectively. Of these patients, 2 were male and 3 were female, with a mean age 68 years old [range $65{\sim}73$]. The number of lesions was 1 in 2 patients, 2 in 2, and 3 in 1. The mean follow up period was 12.6 months [range $8{\sim}16$]. Results : Clinical symptoms and signs in all patients markedly improved within 1 weeks after Novalis radiosurgery. The Karnofsky performance status score was also improved from a pre-radiosurgery average of 68 to a post-radiosurgery one of 82. All of treated lesions showed a partial or complete regression of the original mass. There have been no complication following Novalis radiosurgery. Conclusion : The preliminary results of our experience indicate that radiosurgery with Novalis provides a safe and effective therapeutic alternative treatment of PCNSL in elderly patients.

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