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자료유형
학술저널
저자정보
Moon, Chang-Kiu (College of Pharmacy, Seoul National University) Chung, Jin-Ho (College of Pharmacy, Seoul National University) Lee, You-Mie (College of Pharmacy, Seoul National University) Lee, Soo-Hwan (College of Pharmacy, Seoul National University) Hwang, Gwi-Seo (College of Pharmacy, Seoul National University) Park, Kwang-Sik (College of Pharmacy, Seoul National University) Mock, Myung-Soo (College of Pharmacy, Seoul National University) Kim, Seong-Gon (College of Pharmacy, Seoul National University) Ahn, Young-Soo (College of Pharmacy, Seoul National University) Ann, Jeong-Hee (College of Pharmacy, Seoul National University)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제11권 제2호
발행연도
1988.1
수록면
149 - 154 (6page)

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Impaired erythrocyte deformability was considered to paly an important role in microcirculatory disturbances. We recently confirmed that the brazilin, the main active principle of Caesalpinia sappan, enhanced activity of erythrocyte deformability and reduced blood viscosity. In this study, we examined the effects of brazilin on three biochemical parameters (ATP, 2, 3-diphosphoglycerate, and calcium) which influenced erythrocyte deformability. Treatment with barzilin increased erythrocyte deformability and ATP concentrations in streptozotocin-induced diabetic rats. Concentrations of 2, 3-diphosphoglycerate and calcium in diabetic rats following brazilin administration were decreased significantly compared to those of diabetic control rats. The results suggest that brazilin have a potential effect to improve rheological abnormalities in diabetes.

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