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자료유형
학술저널
저자정보
Shilpi, Jamil Ahmad (Phytochemical and Pharmacological Research Laboratory, Pharmacy Discipline, Life Science School, Khulna University) Rouf, Razina (Phytochemical and Pharmacological Research Laboratory, Pharmacy Discipline, Life Science School, Khulna University) Ferdous, MM (Department of Botany, University of Rajshahi) Uddin, Shaikh Jamal (Phytochemical and Pharmacological Research Laboratory, Pharmacy Discipline, Life Science School, Khulna University)
저널정보
경희한의학연구센터 Oriental pharmacy and experimental medicine Oriental pharmacy and experimental medicine 제6권 제1호
발행연도
2006.1
수록면
21 - 26 (6page)

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The ethanolic extract of Fleurya interrupta Gaud, (Urticaceae) was tested for its possible neuropharmacological effects on experimental animals, For the primary neuropharmacological screening of this plant, the ethanolic extract of its aerial parts was subjected to preliminary evaluation for acute toxicity, antinociceptive activity and central nervous system (CNS) activities. At the doses of 125 and 250 mg/kg, the extract significantly (P < 0.01 and P < 0. 001) and dose-dependently increased the frequency of acetic acid induced writhing in mice. In the pentobarbitone induced sleeping time test, the extract at the above dose levels, significantly and dose-dependently decreased the pentobarbitone induced sleeping time (P < 0.001) and increased the time for onset of sleep (P < 0.001) in mice. In the open field and hole cross tests, test animals showed an increase in their movement in the both tests from the 2nd observation period (30 min) and persisted throughout the entire experimental period (240 min). These results of the extract may attribute a stimulating action on the CNS. On the basis of these findings, it can be assumed that the extract exerts its stimulating effect on the CNS in mice by interfering with the cortical function or increasing the effect of some CNS stimulating neurotransmitters.

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