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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제26권 제10호
- 발행연도
- 2003.1
- 수록면
- 800 - 804 (5page)
이용수
초록· 키워드
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The effects of KR-31378, a neuroprotective agent for ischemia-reperfusion damage, on liver microsomal cytochrome P450s (CYPs) were investigated in male Sprague Dawley rats. When rats were treated orally with KR-31378 for 7 consecutive days, CYP3A-selective erythromycin N-demethylase (ERDM) activity was significantly induced in a dose-dependent manner. In Western immunoblotting, CYP 3A proteins were clearly induced by treatment with KR-31378. Within 24 h after treatment with 80 mg/kg of KR-31378, ERDM activity was induced in liver microsomes in accompanied by induction of the level of CYP 3A proteins. The present results suggest that KR-31378 might modulate the expression of CYP 3A enzymes in humans.
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In Vitro Metabolism of a New Neuroprotective Agent, KR-31543 in the Human Liver Microsomes : Identification of Human Cytochrome P450
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Identification of the cytochrome P450 isoenzymes involved in the metabolism of KR-60436 in the human liver microsomes
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Xylene에 의한 CYP2B1/2의 유도와 대사에 있어서 toluene의 영향
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Importance of Cytochrome P450 3A4 Conformation for the Activity Stimulation by Cytochrome b5 : Specific Inhibition of Cytochrome P450 3A4 by Zinc (II) Ion
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Neuroprotective effect of KR-31378 in cortical cell culture and in brain ischemia-reperfusion model
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IN VITRO METABOLISM OF A NEW PROTON PUMP INHIBITOR KR60436 IN RAT AND HUMAN LIVER MICROSOMES
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