DA-7911, $^{188}Rhenium-tin$ Colloid, as a New Therapeutic Agent of Rheumatoid Arthritis

Shin, Chang-Yell; Son, Miwon; Ko, Jun-Il; Jung, Mi-Young; Lee, In-Ki; Kim, Soon-Hoe; Kim, Won-Bae; Jeong, Jae-Min; Song, Yeong-Wook

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자료유형: 학술저널

저자정보: Shin, Chang-Yell (Research Laboratories, Dong-A Pharm. Co. Ltd.) Son, Miwon (Research Laboratories, Dong-A Pharm. Co. Ltd.) Ko, Jun-Il (Research Laboratories, Dong-A Pharm. Co. Ltd.) Jung, Mi-Young (Research Laboratories, Dong-A Pharm. Co. Ltd.) Lee, In-Ki (Research Laboratories, Dong-A Pharm. Co. Ltd) Kim, Soon-Hoe (Research Laboratories, Dong-A Pharm. Co. Ltd.) Kim, Won-Bae (Research Laboratories, Dong-A Pharm. Co. Ltd.) Jeong, Jae-Min (Cancer Research Institute, Seoul National University College of Medicine) Song, Yeong-Wook (Department of Internal Medicine, College of Medicine, Seoul National University)

저널정보: 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제26권 제2호

발행연도: 2003.1

수록면: 168 - 172 (5page)

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2003

DA-7911, $^{188}Rhenium-tin$ Colloid, as a New Therapeutic Agent of Rheumatoid Arthritis

Shin , Chang-Yell , Son 외 15명 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2003.01 학술저널

2002

DA-7911, rhenium-188 ($Re^{188}$) tin colloid. as a strong candidate agent for radiation synovectomy

Shin , Chang-Yell , Jung 외 9명 대한약학회 학술대회 2002.01 학술대회자료

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Radiation synovectomy is one of the most useful methods for treating patients with refractory synovitis because of its convenience, long-term effects, repeatability and the avoidance of surgery. In this study, we investigated the toxicity, stability and biodistribution of a rhenium-188 ($^{188}$Re)-tin colloid to evaluate its suitability as a synovectomy agent. Twenty four hours after injecting the $^{188}$Re-tin colloids (74 KBq/0.1 mL) into the tail vein of ICR mice, most of the $^{188}$Retin colloidal particles was found in the lungs. In addition, there were no particle size changes at either room temperature or at $37^{\circ}C$ after injecting the $^{188}$Re-tin colloids in human plasma and synovial fluid. In vitro stability tests showed that the $^{188}$Re-tin colloid remained in a colloidal form without a critical size variation over a 2-day period. We investigated the leakage of $^{188}$Retin colloids from the intraarticular injection site with gamma counting in New Zealand white rabbits. The $^{188}$Re-tin colloids (55.5 MBq/0.15 mL) were injected at the cavum articular and the mean retention percentage of the $^{188}$Re-tin colloid was 98.7% for 1 day at the injection site, which suggests that there was neither change in the particle size nor leakage at the injection sites. In the biodistribution study with the SD rats, the liver showed the highest radioactivity (0.0427% ID/organ) except for the injected knees (99.49%). In the SD rats, mild toxicities including the skin or a synovium inflammation were observed as a result of a radioactivity of 15 mCi/kg at the intraarticular injection site. However, there was no systemic toxicity. In the Ovalbumin (OVA)-induced arthritic rabbits, the $^{188}$Re-tin colloid improved the macroscopic, the histological score and reduced the knee joint diameter when compared to the arthritic control. In conclusion, a $^{188}$Re-tin-colloid is considered as a strong candidate for radiation synovectomy with a superior efficacy and safety.

#$^{188}Re-tin$ colloids #Radiation synovectomy #Rheumatoid arthritis

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이 논문의 저자 정보

Shin, Chang-Yell

소속기관 Department of Pharmacology, College of Pharmacy, Chung Ang University

주요연구분야 의약학 > 약학

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Son, Miwon