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논문 기본 정보

자료유형
학술저널
저자정보
Song, Ki-Won (School of Chemical Engineering, Pusan National University) Chang, Gap-Shik (School of Chemical Engineering, Pusan National University) Koo, Ja-Seung (Department of Materials Science & Engineering, Kwangju Institute of Science & Technology)
저널정보
한국유변학회 Korea-Australia rheology journal Korea-Australia rheology journal 제15권 제2호
발행연도
2003.1
수록면
55 - 61 (7page)

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초록· 키워드

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The steady shear flow properties of vaseline generally used as a base of the pharmaceutical dosage forms were studied in the consideration of wall slip phenomenon. The purpose of this study was to show that how slip may affect the experimental steady-state flow curves of semisolid ointment bases and to discuss the ways to eliminate (or minimize) wall slip effect in a rotational rheometer. Using both a strain-controlled ARES rheometer and a stress-controlled AR1000 rheometer, the steady shear flow behavior was investigated with various experimental conditions ; the surface roughness, sample preparation, plate diameter, gap size, shearing time, and loading methods were varied. A stress-controlled rheometer was suitable for investigating the flow behavior of semisolid ointment bases which show severe wall slip effects. In the conditions of parallel plates attached with sand paper, treated sample, smaller diameter fixture, larger gap size, shorter shearing time, and normal force control loading method, the wall slip effects could be minimized. A critical shear stress for the onset of slip was extended to above 10,000 dyne/$\textrm{cm}^2$. The wall slip effects could not be perfectly eliminated by any experimental conditions. However, the slip was delayed to higher value of shear stress by selecting proper fixture properties and experimental conditions.

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