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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제26권 제12호
- 발행연도
- 2003.1
- 수록면
- 990 - 996 (7page)
이용수
초록· 키워드
오류제보하기
A novel carboacyclic nucleoside analogue, 9-[2-bromo-4-hydroxy-3-hydroxymethyl-2-butenyl] adenine, and its derivatives were designed and synthesized as open-chain analogues of neplanocin A. The syntheses were accomplished via the coupling of adenine or pyrimidine bases to the key intermediate allylic bromide 7. The bromide 7 was prepared from epichlorohydrin in a seven step process in a 54% overall yield. The synthesized compounds were evaluated for their antiviral activity against the polio virus, HSV and HIV.
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Synthesis of (-)-Neplanocin A Analogues as Potential Antiviral Agents
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2000 .01
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Synthesis and Biological Evaluation of 9-[2-Fluoro-4-hydroxy-3-hydroxymethyl-2-butenyl]adenine and its Related Compounds as Open-chain Analogues of Neplanocin A
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
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DESIGN, SYNTHESIS AND IN VITRO EVALUATION OF APIO ANALOGUE OF NEPLANOCIN A
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Design, Synthesis, And In Vitro Evaluation of Apio Analogs of Neplanocin A and Aristeromycin
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Structure-activity Relationship Study of Fluoro-Neplanocin A as Potential Antiviral and Antitumor Agents
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Straightforward synthesis of 4'${\alpha}$-C-hydroxymethyl branched novel carbocyclic nucleosides
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1,4-위치에 측쇄를 가진 신규 뉴크레오사이드의 합성 및 항바이러스 약효검색
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Synthesis and Antiviral Activity of Novel trans-2,2-Dimethyl Cyclopropyl Nucleosides
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Inactivation of S-Adenosylhomocysteine Hydrolase by Fluoro-neplanocin A
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The first synthesis of 4' ${\alpha}$-C aryl branched carbocyclic nucleosides
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Synthesis and Antiviral Activity of Novel Methylene Cyclopropyl Nucleosides
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Synthesis and Biological Evaluation of Pyrimidine Nucleosides Fused with 3′,4′- Tetrahydrofuran Ring
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Synthesis of Novel 3′-Deoxy-3′-c-hydroxymethyl Nucleosides with Conformationally Right Sugar Moiety as Potential Antiviral Agents
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Synthesis of Novel 2'-Methyl Carbovir Analogues as Potent Antiviral Agents
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Synthesis and Antiviral Activity of Methylene Cyclopropyl Pyrimidine Nucleosides
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Synthesis and Antiviral Activity of Novel C-Methyl Branched Cyclopropyl Nucleosides
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Synthesis of Some Cyclopropyl Nucleosides as Potential Antiviral Agents
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2000 .01
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4',5'-측쇄를 가진 새로운 피리미딘 뉴크레오사이드의 합성 및 항바이러스 약효검색
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2005 .01
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새로운 사이클로프로필 뉴크레오사이드 유도체의 합성과 생리활성
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C-뉴크레오사이드의 화학합성
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