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자료유형
학술저널
저자정보
Shin, Hye-Young (Department of Oriental Pharmacy, Wonkwang University) Lee, Kyung-Bo (College of Pharmacy, Woosuk University) Jung, Yun-Hee (College of Pharmacy, Woosuk University) Kim, Eun-Ah (College of Pharmacy, Woosuk University) Lee, Mi-Young (College of Pharmacy, Woosuk University) Lee, Mi-Ri (College of Pharmacy, Woosuk University) Kim, Sang-Yong (College of Agriculture, Jeonbuk National University) Kim, Sang-Hyun (Department of Physiology and Pharmacology, University of Georgia) Shin, Tae-Yong (College of Pharmacy, Woosuk University)
저널정보
경희한의학연구센터 Oriental pharmacy and experimental medicine Oriental pharmacy and experimental medicine 제3권 제2호
발행연도
2003.1
수록면
56 - 62 (7page)

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The effect of aqueous extract of Terminalia chebula fruit (Combretaceae) (TCAE) by anal administration on mast cell-dependent immediate-type anaphylactic reactions was investigated. TCAE (0.005 to 1 g/kg) inhibited systemic anaphylaxis induced by compound 48/80 in mice. When TCAE was pretreated at the same concentrations with systemic anaphylaxis, the plasma histamine levels were reduced in a dose-dependent manner. TCAE (0.1 and 1 g/kg) also significantly inhibited local anaphylaxis activated by anti-DNP IgE. TCAE (0.001 to 1 mg/ml) dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. Moreover, TCAE (0.01 and 0.1 mg/ml) had a significant inhibitory effect on anti-DNP IgE-mediated tumor necrosis $factor-{\alpha}$ $(TNF-{\alpha})$ production from RPMC. These results provide evidence that anal therapy of TCAE may be beneficial in the treatment of systemic and local mast cell-dependent anaphylaxis.

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