Three-Dimensional Porous Collagen/Chitosan Complex Sponge for Tissue Engineering

Kim, Sung Eun; Cho, Yong Woo; Kang, Eun Jung; Kwon, Ick Chan; Lee, Eunhee Bae; Kim, Jung Hyun; Chung, Hesson; Jeong, Seo Young

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자료유형: 학술저널

저자정보: Kim, Sung Eun (Biomedical Research Center, Korea Institute of Science and Technology & Department of Chemical Engineering, Yonsei University) Cho, Yong Woo (Biomedical Research Center, Korea Institute of Science and Technology) Kang, Eun Jung (Biomedical Research Center, Korea Institute of Science and Technology) Kwon, Ick Chan (Biomedical Research Center, Korea Institute of Science and Technology) Lee, Eunhee Bae (Biomedical Research Center, Korea Institute of Science and Technology) Kim, Jung Hyun (Biomedical Research Center, Korea Institute of Science and Technology & Department of Chemical Engineering, Yonsei University) Chung, Hesson (Biomedical Research Center, Korea Institute of Science and Technology) Jeong, Seo Young (Biomedical Research Center, Korea Institute of Science and Technology)

저널정보: 한국섬유공학회 Fibers and Polymers Fibers and polymers 제2권 제2호

발행연도: 2001.1

수록면: 64 - 70 (7page)

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A three-dimensional, porous collagen/chitosan complex sponge was prepared to closely simulate basic extracellular matrix (ECM) constitutes, collagen and glycosaminoglycan. The complex sponge was prepared by a lyophilization method and had the regular network with highly porous structure, suitable for cell adhesion and growth. The pores were well interconnected, and their distribution was fairly homogeneous. The complex sponge was crosslinked using 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide (NHS) to increase its boilogical stability and enhance its mechanical properties. The crosslinking medium has a great effect on the inner structure of the sponge. The homogeneous, porous structure of the sponge was remarkably collapsed in an aqueous crosslinking medium. However, the morphology of the sponge remained almost intact in a water/ethanol mixture crosslinking milieu. Mechanical properties of the collagen/chitosan sponge were significantly enhanced by EDC-mediated crosslinking. The potential of the sponge as a scaffold for tissue engineering was investigated using a Chinese hamster ovary cell (CHO-K1) line.

#Collagen #Chitosan #Scaffold #Sponge #Pore #Mechanical Properties #CHO cell #Tissue engineering

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Kim, Sung Eun

소속기관 Biomedical Research Center, Korea Institute of Science and Technology & Department of Chemical E