지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제24권 제6호
- 발행연도
- 2001.1
- 수록면
- 607 - 612 (6page)
이용수
초록· 키워드
오류제보하기
Endogenous carbon monoxide (CO) shares with nitric oxide (NO) a role as a putative neural messenger in the brain. Both gases are believed to modulate CNS function via an increase in cytoplasmic cGMP concentrations secondary to the activation of soluble guanylate cyclase (sGC). Recently CO and NO were proposed as a possible mediator of febrile response in hypothalamus. NO has been reported to activate both the constitutive and inducible isoform of the cyclooxygenase (COX). Thus, we investigated whether CO arising from heme catabolism by heme oxygenate (HO) is involved in the febrile response via the activation of COX in the hypothalamus. $PGE_2$ which is a final mediator of febrile response released from primary cultured hypothalamic cells was taken as a marker of COX activity. $PGE_2$ concentration was measured with EIA kits. Exogenous CO (CO-saturated medium) and hemin (a substrate and potent inducer of HO) evoked an increase in $PGE_2$ release from hypothalamic cells, and these effects were blocked by methylene blue (an inhibitor of sGC). And membrane permeable cGMP analogue, dibutyryl-cGMP elicited significant increases in $PGE_2$release. These results suggest that there may be a functional link between HO and COX enzymatic activities. The gaseous product of hemin through the HO pathway, CO, might play a role through the modulation of the COX activity in the hypothalamus.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Carbon Monoxide as a Novel Central Pyrogenic Mediator
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2002 .01
-
Effects of hemin on the cyclooxygenase in the primary cultured hypothalamic cells
대한약학회 학술대회
2000 .01
-
Heme Oxygenase-1 : Its Therapeutic Roles in Inflammatory Diseases
Immune Network
2009 .02
-
Heme Oxygenase Inducers from Natural Products
한국응용약물학회 춘계학술발표논문집
2004 .01
-
Immunosuppressive Effects of Carbon Monoxide, a Gaseous Product of Heme Oxygenase-1
대한약학회 학술대회
2005 .01
-
Asthma is protected by heme oxygenase-1 and its enzymatic product, carbon monoxide (CO)
한국실험동물학회 학술발표대회 논문집
2004 .06
-
LPS로 활성화된 U937세포에서 Prostaglandin $E_2\;(PGE_2)$ 생성 및 Cyclooxygenase-2 (COX-2) 활성 억제에 대한 한약제의 평가
동의생리병리학회지
2006 .01
-
Up-regulation of Heme Oxygenase-1 Expression by cAMP-elevating Agents in RAW 264.7 cells
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2002 .01
-
ICR mouse의 피부와 간에서 자외선 B파에 의한 Heme Oxygenase-1의 유도
한국환경보건학회지
2008 .01
-
Pathophysiology and clinical characteristics of hypothalamic obesity in children and adolescents
Annals of Pediatirc Endocrinology & Metabolism
2013 .01
-
폐암세포주에서 Heme Oxygenase-1의 역할
Tuberculosis and Respiratory Diseases
2006 .01
-
Evaluation of Cytotoxicity Effects of Chalcone Epoxide Analogues as a Selective COX-II Inhibitor in the Human Liver Carcinoma Cell Line
Journal of Pharmacopuncture
2017 .01
-
Lipopolysaccharide에 의한 Heme Oxygenase Induction과 Carbon Monoxide생성이 혈관수축력에 미치는 영향
약학회지
2001 .01
-
Heme Oxygenase-1 in Tumors: Therapeutic Implications
대한약학회 학술대회
2005 .01
-
Tamoxifen affects heme oxygenase-1 (HO-1) expression in MCF-7 human breast cancer cell line
대한외과학회 학술대회 초록집
2019 .10
-
진행성 비소세포폐암에서 Heme oxygenase-1 발현과 Cisplatin을 포함하는 항암화학요법의 치료반응과의 연관성
Tuberculosis and Respiratory Diseases
2006 .01
-
Heme oxygenase-1 유도를 통한 화학 암예방 및 세포보호와 그 분자생물학적 기전
한국환경성돌연변이·발암원학회지
2006 .12
-
Interrelationship between the IL-1$\beta$-induced pyresis and heme oxygenase in hypothalamus
대한약학회 학술대회
2000 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0