지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제23권 제1호
- 발행연도
- 2000.1
- 수록면
- 35 - 41 (7page)
이용수
초록· 키워드
오류제보하기
In order to investigate the stereochemical requirements of planar structure at 4-position of 4-phenyl-1-arylsulfonylimidazolidinones (1) for their cytoxicities against human cancer cell lines, the size, the distance from imidazolidinone ring, and the conformation of this moiety were variegated. Replacement of phenyl moiety with naphthyl in compounds 2 and 3 or benzyl moiety in compound 4 sharply reduced activity of 1. Conformational restriction on phenyl ring in compound 5 also resulted in the loss of activity of 1. Therefore, phenyl moiety without any substituents directly attached to imidazolidinone ring of 1 should be considered as an essential pharmacophore for this analog.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Importance of phenyl moiety for cytotoxicity of 4-Phenyl-1-arylsulfonylimidazolidinones
대한약학회 학술대회
2000 .01
-
Evaluation of the Role of Imidazolidinone Motif of Antineoplastic 4-Phenyl-1-arylsulfonylimidazolidinones Using 4-Phenyl-2-arylsulfonyloxazolines
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2001 .01
-
Effect of Substituents on Benzenesulfonyl Motif of 4-Phenyl-1-arylsulfonylimidazolidinones for Their Cytotoxicity
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2000 .01
-
Recognition of the Importance of Imidazolidinone Motif for Cytotoxicity of 4-Phenyl-1-arylsulfonylimidazolidinones Using Thiadiazolidine-1, 1-Dioxide Analogs
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2002 .01
-
Synthesis and Evaluation of Cytotoxicity of Novel Arylsulfonylimidazolidinones Containing Sulfonylurea Pharmacophore
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1996 .01
-
Importance of Sulfonylimidazolidinone Motif of 4-Phenyl-1-arylsulfonylimidazolidinones for Their Cytotoxicity: Synthesis of 2-Benzoyl-4-phenyl[1,2,5]thiazolidine-1,1-dioxides and Their Cytotoxcity
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2003 .01
-
New Arylsulfonylimidazolidinones as Hypoxia Selective Anticancer Agent
한국응용약물학회 추계학술발표논문집
2002 .01
-
Planar Structural Requirement at 4-position of 1-Arylsulfonyl-4-phenyl-4,5-dihydro-2-imidazolones for their Cytotoxicity
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1997 .01
-
Cytotoxicity Antimicrobial activity of Geranyl phenyl ethers
대한약학회 학술대회
2001 .01
-
CoMFA of 1-phenyl-2-substituted thioureas for their cytotoxicity
대한약학회 학술대회
2002 .01
-
Evaluation of Anticancer Activity of 4-Vinyl-1-Arylsulfonylimidazolidinones
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2006 .01
-
CoMFA analysis of 2-phenyl-1,8-naphthyridin-4-ones for cytotoxicity
대한약학회 학술대회
2001 .01
-
Proteomic Analysis and the Antimetastatic Effect of N-(4methyl)phenyl-O-(4-methoxy) phenyl-thionocarbamate-Induced Apoptosis in Human Melanoma SK-MEL-28 cells
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2006 .01
-
CoMFA Analysis of 2-Alkylureido-1-phenyl propanols for Cytotoxicity
대한약학회 학술대회
2001 .01
-
Phenyl Vinyl Ether와 그 Epoxide 화합물의 발암성 실험 ( Carcinogenicity of Phenyl Vinyl Ether and its Epoxide )
한국환경성돌연변이·발암원학회지
1997 .09
-
Synthesis, Cytotoxicity and Antitumor Activity of 2,3-Diarylcyclopent-2-ene-1-ones
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2002 .01
-
Revisit to Unfulfilled Premise of Arylsulfonylimidazolidinones as Anticancer Agent
대한약학회 학술대회
2002 .01
-
The 3-D QSAR study of antitumor arylsulfonylimidazolidinone derivatives by CoMFA and COMSIA
대한약학회 학술대회
2002 .01
-
Synthesis of 2-phenyl-1,8-naphthyridin-4-ones
대한약학회 학술대회
2003 .01
-
Structure Activity Relationship of ar-Turmerone Analogues
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1993 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0