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논문 기본 정보

자료유형
학술저널
저자정보
Yang Jae-Heon (Department of Pharmacy, Woosuk University) Kim Dae-Keun (Department of Pharmacy, Woosuk University) Yun Mi-Young (Department of Pharmacy, Woosuk University) Kim Tae-Youl (Department of Physical Therapy, Dongshin University) Shin Sang-Chul (College of Pharmacy, Chonnam National University)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제29권 제5호
발행연도
2006.1
수록면
412 - 417 (6page)

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Triamcinolone acetonide (TA) is a corticosteroid that is used in the systemic and topical treatment of many inflammatory diseases. In this study, a phonophoretic drug delivery system was designed to enhance the TA permeability and the influence of ultrasound was examined. In order to establish the transdermal delivery system for TA, a hydrophilic carbopol gel containing TA was prepared after adopting phonophoresis. A permeation study through mouse skin was performed at $37^{\circ}C$ using a Franz diffusion cell, and the ultrasound treatment was carried out for 10 h. The level of TA permeation through the skin was evaluated under various ultrasound conditions including the frequency (1.0, 3.0 MHz), intensity (1.0, $2.5W/cm^2 $), and duty cycle (continuous, pulse mode) using a 0.5% TA gel. The highest permeation was observed under the ultrasound treatment conditions of low frequency, high intensity, and in continuous mode.

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